A multi-laboratory preclinical trial in rodents to assess treatment candidates for acute ischemic stroke
Human diseases may be modeled in animals to allow preclinical assessment of putative
new clinical interventions. Recent, highly publicized failures of large clinical trials called into …
new clinical interventions. Recent, highly publicized failures of large clinical trials called into …
Minimal clinically important difference of scales reported in stroke trials: a review
There is a growing awareness of the significance of using minimum clinically important
differences (MCIDs) in stroke research. An MCID is the smallest change in an outcome …
differences (MCIDs) in stroke research. An MCID is the smallest change in an outcome …
CNS drug delivery in stroke: improving therapeutic translation from the bench to the bedside
Drug development for ischemic stroke is challenging as evidenced by the paucity of
therapeutics that have advanced beyond a phase III trial. There are many reasons for this …
therapeutics that have advanced beyond a phase III trial. There are many reasons for this …
Biological and procedural predictors of outcome in the Stroke Preclinical Assessment Network (SPAN) trial
BACKGROUND: The SPAN trial (Stroke Preclinical Assessment Network) is the largest
preclinical study testing acute stroke interventions in experimental focal cerebral ischemia …
preclinical study testing acute stroke interventions in experimental focal cerebral ischemia …
Cofilactin rod formation mediates inflammation-induced neurite degeneration
Stroke, trauma, and neurodegenerative disorders cause loss of neurites (axons and
dendrites) in addition to neuronal death. Neurite loss may result directly from a primary …
dendrites) in addition to neuronal death. Neurite loss may result directly from a primary …
Uric acid: a translational journey in cerebroprotection that spanned preclinical and human data
Uric acid (UA) is a strong endogenous antioxidant that neutralizes the toxicity of peroxynitrite
and other reactive species on the neurovascular unit generated during and after acute brain …
and other reactive species on the neurovascular unit generated during and after acute brain …
An update on stem cell therapy for stroke patients: Where are we now?
With a foundation built upon initial work from the 1980s demonstrating graft viability in
cerebral ischemia, stem cell transplantation has shown immense promise in promoting …
cerebral ischemia, stem cell transplantation has shown immense promise in promoting …
Embracing heterogeneity in the multicenter Stroke Preclinical Assessment Network (SPAN) trial
The Stroke Preclinical Assessment Network (SPAN) is a multicenter preclinical trial platform
using rodent models of transient focal cerebral ischemia to address translational failure in …
using rodent models of transient focal cerebral ischemia to address translational failure in …
Climbing the STAIRs to SPAN the clinical translation gap: recent advances in multicenter preclinical stroke trials
The earliest published randomized controlled multicenter preclinical stroke trial assessed
the potential for anti-CD49d antibodies to inhibit the inflammatory response. 7 This treatment …
the potential for anti-CD49d antibodies to inhibit the inflammatory response. 7 This treatment …
[HTML][HTML] Evolving Clinical–Translational Investigations of Cerebroprotection in Ischemic Stroke
Y Li, LE Schappell, C Polizu, J DiPersio… - Journal of Clinical …, 2023 - mdpi.com
Ischemic stroke is a highly morbid disease, with over 50% of large vessel stroke (middle
cerebral artery or internal carotid artery terminus occlusion) patients suffering disability …
cerebral artery or internal carotid artery terminus occlusion) patients suffering disability …