Gene drives gaining speed

E Bier - Nature Reviews Genetics, 2022 - nature.com
Gene drives are selfish genetic elements that are transmitted to progeny at super-Mendelian
(> 50%) frequencies. Recently developed CRISPR–Cas9-based gene-drive systems are …

The one health concept

SJ Pitt, A Gunn - British Journal of Biomedical Science, 2024 - frontierspartnerships.org
The concept of One Health has been developed as the appreciation that human health is
intricately connected to those of other animals and the environment that they inhabit. In …

An Updated View of the Trypanosoma cruzi Life Cycle: Intervention Points for an Effective Treatment

J Martín-Escolano, C Marín, MJ Rosales… - ACS Infectious …, 2022 - ACS Publications
Chagas disease (CD) is a parasitic, systemic, chronic, and often fatal illness caused by
infection with the protozoan Trypanosoma cruzi. The World Health Organization classifies …

Global, regional, and national trends of Chagas disease from 1990 to 2019: comprehensive analysis of the global burden of disease study

SA Gómez-Ochoa, LZ Rojas, LE Echeverría… - Global …, 2022 - pmc.ncbi.nlm.nih.gov
Background: Chagas disease (CD) is a neglected tropical disease, endemic in Latin
America, but due to migration and environmental changes it has become a global public …

Worldwide control and management of Chagas disease in a new era of globalization: a close look at congenital Trypanosoma cruzi infection

A Abras, C Ballart, A Fernández-Arévalo… - Clinical microbiology …, 2022 - journals.asm.org
Population movements have turned Chagas disease (CD) into a global public health
problem. Despite the successful implementation of subregional initiatives to control vectorial …

Harnessing RNA technology to advance therapeutic vaccine antigens against Chagas disease

C Mancino, J Pollet, A Zinger, KM Jones… - … Applied Materials & …, 2024 - ACS Publications
Chagas disease (CD)(American trypanosomiasis caused by Trypanosoma cruzi) is a
parasitic disease endemic in 21 countries in South America, with increasing global spread …

Diagnosis and clinical management of Chagas disease: An increasing challenge in non-endemic areas

C Suárez, D Nolder, A García-Mingo… - … and reports in …, 2022 - pmc.ncbi.nlm.nih.gov
Chagas disease (CD) is caused by the parasite Trypanosoma cruzi, and it is endemic in
Central, South America, Mexico and the South of the United States. It is an important cause …

[HTML][HTML] Ruthenium complexes in the fight against pathogenic microorganisms. An extensive review

AC Munteanu, V Uivarosi - Pharmaceutics, 2021 - mdpi.com
The widespread use of antibiotics has resulted in the emergence of drug-resistant
populations of microorganisms. Clearly, one can see the need to develop new, more …

[HTML][HTML] Chagas disease in Europe

M Gonzalez-Sanz, C Crespillo-Andújar… - Tropical Medicine and …, 2023 - mdpi.com
Chagas disease is currently present in many non-endemic countries and remains a
neglected tropical disease globally. A review of the literature identified significant gaps and …

Review on Experimental Treatment Strategies Against Trypanosoma cruzi

AL Mazzeti, P Capelari-Oliveira, MT Bahia… - Journal of …, 2021 - Taylor & Francis
Chagas disease is a neglected tropical disease caused by the protozoan Trypanosoma
cruzi. Currently, only nitroheterocyclic nifurtimox (NFX) and benznidazole (BNZ) are …