Advances in the molecular understanding of facioscapulohumeral muscular dystrophy
(FSHD) have revealed that FSHD results from epigenetic de-repression of the DUX4 gene in …

Background Physical and functional losses due to aging and diseases decrease human
mobility, independence, and quality of life. This study is aimed at summarizing and …

Abstract Facioscapulohumeral dystrophy (FSHD; MIM 158900, MIM 158901) is caused by
misexpression of the DUX4 transcription factor in skeletal muscle. Animal models of FSHD …

Background Facioscapulohumeral muscular dystrophy is a hereditary progressive myopathy
caused by aberrant expression of the transcription factor DUX4 in skeletal muscle. No …

Facioscapulohumeral muscular dystrophy (FSHD) is caused by chromatin relaxation that
results in aberrant expression of the transcription factor Double Homeobox 4 (DUX4). DUX4 …

In the last decade, the sequence-specific transcription factor double homeobox 4 (DUX4)
has gone from being an obscure entity to being a key factor in important physiological and …

During the past decade, the search for pathogenic mutations in rare human genetic
diseases has involved huge efforts to sequence coding regions, or the entire genome, using …

Facioscapulohumeral muscular dystrophy (FSHD: MIM# 158900) is a common myopathy
with marked but largely unexplained clinical inter-and intra-familial variability. It is caused by …

A reliable model of a disease pathomechanism is the first step to develop targeted treatment.
In facioscapulohumeral muscular dystrophy (FSHD), the third most common muscular …

Facioscapulohumeral muscular dystrophy (FSHD) is a common, dominantly inherited
disease caused by the epigenetic de-repression of the DUX4 gene, a transcription factor …