Short read massive parallel sequencing has emerged as a standard diagnostic tool in the
medical setting. However, short read technologies have inherent limitations such as GC …

In recent years long-read technologies have moved from being a niche and specialist field to
a point of relative maturity likely to feature frequently in the genomic landscape. Analogous …

Whole-genome sequencing (WGS) of pathogens is becoming increasingly important not
only for basic research but also for clinical science and practice. In virology, WGS is …

Long-read sequencing (LRS) has become increasingly popular due to its strengths in de
novo assembly and in resolving complex DNA regions as well as in determining full-length …

Abstract Background Hepatitis C (HCV) and many other RNA viruses exist as rapidly
mutating quasi-species populations in a single infected host. High throughput …

Identification of the causative infectious agent is essential in the management of infectious
diseases, with the ideal diagnostic method being rapid, accurate, and informative, while …

In recent years, the development of diagnostics using artificial intelligence (AI) has been
remarkable. AI algorithms can go beyond human reasoning and build diagnostic models …

Background Microelimination of the hepatitis C virus (HCV) among men who have sex with
men (MSM) could be complicated by continuous external introductions and the emergence …

Hepatitis C virus (HCV) is one of very few viruses that are either naturally cleared, or
alternatively persist to cause chronic disease. Viral diversity and escape, as well as host …

The changes occurring in viral quasispecies populations during infection have been
monitored using diversity indices, nucleotide diversity, and several other indices to …