Analysis of shared heritability in common disorders of the brain

Brainstorm Consortium, V Anttila, B Bulik-Sullivan… - Science, 2018 - science.org
INTRODUCTION Brain disorders may exhibit shared symptoms and substantial
epidemiological comorbidity, inciting debate about their etiologic overlap. However, detailed …

Behavioral and psychological symptoms of dementia

J Cerejeira, L Lagarto… - Frontiers in neurology, 2012 - frontiersin.org
Behavioral and psychological symptoms of dementia (BPSD), also known as
neuropsychiatric symptoms, represent a heterogeneous group of non-cognitive symptoms …

2012 Alzheimer's disease facts and figures

Alzheimer's Association - Alzheimer's & dementia, 2012 - Elsevier
This report provides information to increase understanding of the public health impact of
Alzheimer's disease (AD). Topics addressed include incidence, prevalence, mortality rates …

[HTML][HTML] Analysis of shared heritability in common disorders of the brain

Brainstorm Consortium - Science (New York, NY), 2018 - ncbi.nlm.nih.gov
Disorders of the brain can exhibit considerable epidemiological comorbidity and often share
symptoms, provoking debate about their etiologic overlap. We quantified the genetic sharing …

Dementia caregiver burden: a research update and critical analysis

ST Cheng - Current psychiatry reports, 2017 - Springer
Abstract Purpose of Review This article provides an updated review of the determinants of
caregiver burden and depression, with a focus on care demands and especially the …

Family caregiving of persons with dementia: prevalence, health effects, and support strategies

R Schulz, LM Martire - The American journal of geriatric psychiatry, 2004 - Elsevier
The authors summarize the dementia caregiving literature and provide recommendations
regarding practice guidelines for health professionals working with caregivers. Family …

The American Psychiatric Association practice guideline on the use of antipsychotics to treat agitation or psychosis in patients with dementia

VI Reus, LJ Fochtmann, AE Eyler… - American Journal of …, 2016 - Am Psychiatric Assoc
The goal of this guideline is to improve the care of patients with dementia who are exhibiting
agitation or psychosis. More specifically, this guideline focuses on the judicious use of …

An overview of systematic reviews of pharmacological and non-pharmacological interventions for the treatment of behavioral and psychological symptoms of dementia

SM Dyer, SL Harrison, K Laver… - International …, 2018 - cambridge.org
Background: This systematic overview reports findings from systematic reviews of
randomized controlled trials of pharmacological and non-pharmacological interventions for …

Pharmacological treatment of neuropsychiatric symptoms of dementia: a review of the evidence

KM Sink, KF Holden, K Yaffe - Jama, 2005 - jamanetwork.com
ContextNeuropsychiatric symptoms of dementia are common and associated with poor
outcomes for patients and caregivers. Although nonpharmacological interventions should be …

Apathy in Parkinson's disease: clinical features, neural substrates, diagnosis, and treatment

J Pagonabarraga, J Kulisevsky, AP Strafella… - The Lancet …, 2015 - thelancet.com
Normal maintenance of human motivation depends on the integrity of subcortical structures
that link the prefrontal cortex with the limbic system. Structural and functional disruption of …