Abstract Purpose of Review This article provides an updated review of the determinants of
caregiver burden and depression, with a focus on care demands and especially the …

INTRODUCTION Brain disorders may exhibit shared symptoms and substantial
epidemiological comorbidity, inciting debate about their etiologic overlap. However, detailed …

Disorders of the brain can exhibit considerable epidemiological comorbidity and often share
symptoms, provoking debate about their etiologic overlap. We quantified the genetic sharing …

Background: This systematic overview reports findings from systematic reviews of
randomized controlled trials of pharmacological and non-pharmacological interventions for …

Background: Dementia is a neurological condition characterized by deterioration in
cognitive, behavioral, social, and emotional functions. Pharmacological interventions are …

The goal of this guideline is to improve the care of patients with dementia who are exhibiting
agitation or psychosis. More specifically, this guideline focuses on the judicious use of …

This report provides information to increase understanding of the public health impact of
Alzheimer's disease (AD). Topics addressed include incidence, prevalence, mortality rates …

Normal maintenance of human motivation depends on the integrity of subcortical structures
that link the prefrontal cortex with the limbic system. Structural and functional disruption of …

Behavioral and psychological symptoms of dementia (BPSD), also known as
neuropsychiatric symptoms, represent a heterogeneous group of non-cognitive symptoms …

Importance Agitation is common, persistent, and associated with adverse consequences for
patients with Alzheimer disease. Pharmacological treatment options, including …