Executive summary “Depression is a disorder of mood, so mysteriously painful and elusive
in the way it becomes known to the self—to the mediating intellect—as to verge close to …

Major depression is one of the most prevalent and debilitating personal and public health
conditions worldwide. Less appreciated is that depression's tremendous burdens are not …

Cognitive behavior therapy (CBT) is by far the most examined type of psychological
treatment for depression and is recommended in most treatment guidelines. However, no …

Objective Meta‐analyses of psychotherapies usually report effects sizes, while clinicians
and patients need to know the proportion of patients who benefit from therapy. We …

Treatments for depression have improved, and their availability has markedly increased
since the 1980s. Mysteriously the general population prevalence of depression has not …

Criteria for treatment-resistant depression (TRD) and partially responsive depression (PRD)
as subtypes of major depressive disorder (MDD) are not unequivocally defined. In the …

Major depression is a leading contributor to the global burden of disease. This situation is
mainly related to the chronicity and/or recurrence of the disorder, and to poor response to …

Importance Approximately 9% of US adults experience major depression each year, with a
lifetime prevalence of approximately 17% for men and 30% for women. Observations Major …

Objective: In addition to N-methyl-d-aspartate receptor antagonism, ketamine produces
opioid system activation. The objective of this study was to determine whether opioid …

Importance Postpartum depression (PPD) is one of the most common medical complications
during and after pregnancy, negatively affecting both mother and child. Objective To …