Epigenetic regulatory mechanisms, including DNA methylation, histone modification,
chromatin remodeling, and microRNA expression, play critical roles in cell differentiation …

Stress is a primary risk factor for several neuropsychiatric disorders. Evidence from
preclinical models and clinical studies of depression have revealed an array of structural …

Mood disorders are common and debilitating conditions characterized in part by profound
deficits in reward-related behavioural domains. A recent literature has identified important …

Chronic stressful life events are risk factors for develo** major depression, the
pathophysiology of which is strongly linked to impairments in serotonin (5-HT) …

Stress-related neuropsychiatric disorders, such as major depressive disorder and
posttraumatic stress disorder, exact enormous socioeconomic and individual consequences …

To date, there is rapidly increasing evidence for host–microbe interaction at virtually all
levels of complexity, ranging from direct cell‐to‐cell communication to extensive systemic …

Investigations of long-term changes in brain structure and function that accompany chronic
exposure to drugs of abuse suggest that alterations in gene regulation contribute …

Unravelling the pathophysiology of depression is a unique challenge. Not only are
depressive syndromes heterogeneous and their aetiologies diverse, but symptoms such as …

Variations in phenotype reflect the influence of environmental conditions during
development on cellular functions, including that of the genome. The recent integration of …

Chromatin modifications, especially histone-tail acetylation, have been implicated in
memory formation. Increased histone-tail acetylation induced by inhibitors of histone …