[HTML][HTML] The role of nuclear factor kappa B (NF-κB) in the immune response against parasites

P Bąska, LJ Norbury - Pathogens, 2022 - mdpi.com
The immune system consists of various cells, organs, and processes that interact in a
sophisticated manner to defend against pathogens. Upon initial exposure to an invader …

Zooming in on common immune evasion mechanisms of pathogens in phagolysosomes: potential broad-spectrum therapeutic targets against infectious diseases

A Selvapandiyan, N Puri, P Kumar… - FEMS Microbiology …, 2023 - academic.oup.com
The intracellular viral, bacterial, or parasitic pathogens evade the host immune challenges to
propagate and cause fatal diseases. The microbes overpower host immunity at various …

Targeting and activation of macrophages in leishmaniasis. A focus on iron oxide nanoparticles

C Palomino-Cano, E Moreno, JM Irache… - Frontiers in …, 2024 - frontiersin.org
Macrophages play a pivotal role as host cells for Leishmania parasites, displaying a notable
functional adaptability ranging from the proinflammatory, leishmanicidal M1 phenotype to …

In vitro characterization of Trypanosoma cruzi infection dynamics in skeletal and cardiac myotubes models suggests a potential cell-to-cell transmission in mediating …

JME Contreras-Ortiz… - PLOS Neglected …, 2024 - journals.plos.org
Chagas disease predominantly affects the heart, esophagus, and colon in its chronic phase.
However, the precise infection mechanisms of the causal agent Trypanosoma cruzi in these …

Involvement of Akt and the antiapoptotic protein Bcl‐xL in the inhibition of apoptosis of dendritic cells by Leishmania mexicana

J Rodríguez‐González… - Parasite …, 2022 - Wiley Online Library
The intracellular parasite Leishmania mexicana inhibits camptothecin (CPT)‐induced
apoptosis of monocyte‐derived dendritic cells (moDC) through the down‐regulation of p38 …

The role of NF-κB transcription factor in the regulation of cytokine induced thermal hyperalgesia in a Leishmania major model in BALB/c mice

R Hoblos, K Khalil, M Karam, S Bazzi - Experimental Parasitology, 2024 - Elsevier
Cutaneous leishmaniasis caused mainly by Leishmania major (L. major) is one of the
trending models used to investigate induced hyperalgesia and the involved cytokines …

Discovering the Potent Inhibitors Against Babesia bovis in vitro and Babesia microti in vivo by Repurposing the Natural Product Compounds

Y Li, MA Rizk, EM Galon, M Liu, J Li… - Frontiers in Veterinary …, 2021 - frontiersin.org
In the present study, we screened 502 natural product compounds against the in vitro growth
of Babesia (B.) bovis. Then, the novel and potent identified compounds were further …

Immunomodulators: Progress and prospects in Leishmania infection

S Mandal, W Ansar, JJ Jawed - Viral, parasitic, bacterial, and fungal …, 2023 - Elsevier
Leishmaniasis is a group of tropical infectious diseases that are often overlooked. And
hence is now listed as Neglected Tropical Disease (NTD) under WHO. It is prevalent in 88 …

Modulation of ERK and AKT pathways as the potential therapeutic targets for Toxoplasma gondii infection

R Hosseini, N Panahi - Journal of Zoonotic Diseases, 2024 - jzd.tabrizu.ac.ir
Toxoplasmosis is a zoonotic disease caused by Toxoplasma gondii, which can infect
humans through oocysts or undercooked meat. It can cause varying symptoms, including …

Effect of the cell-growth rate on the invasion and infection efficacy of Trypanosoma cruzi trypomastigotes, and the potential cell-to-cell transfer of the parasite

E Escabia Herrando - 2022 - diva-portal.org
Recent studies proposed that mammalian cell lines with slower growth rates were infected
more efficiently by Trypanosoma cruzi, and that cell-to-cell transmission could be occurring …