Macroautophagy/autophagy is a cellular catabolic process that results in lysosome-
mediated recycling of organelles and protein aggregates, as well as the destruction of …

Autophagy is an evolutionarily conserved catabolic mechanism, by which eukaryotic cells
recycle or degrades internal constituents through membrane-trafficking pathway. Thus …

Background Ageing is the inevitable time-dependent decline in physiological organ function
that eventually leads to death. Age is a major risk factor for many of the most common …

Life and health span can be prolonged by calorie limitation or by pharmacologic agents that
mimic the effects of caloric restriction. Both starvation and the genetic inactivation of nutrient …

Autophagy is a crucial recycling process that is increasingly being recognized as an
important factor in cancer initiation, cancer (stem) cell maintenance as well as the …

Colorectal cancer (CRC), despite numerous therapeutic and screening attempts, still
remains a major life-threatening malignancy. CRC etiology entails both genetic and …

At a time when complex diseases affect globally 280 million people and claim 14 million
lives every year, there is an urgent need to rapidly increase our knowledge into their …

Colorectal cancer is one of the leading causes of cancer-associated mortality worldwide.
The limitations of colorectal cancer treatment include various types of multidrug resistance …

Previous studies demonstrated significant roles of autophagy in the pathogenesis of sepsis,
but few studies focused on the effect of autophagy-related SNPs on sepsis susceptibility. In …

Background In cancer cells, autophagy can act as both tumor suppressor, when autophagic
event eliminates cellular contends which exceeds the cellular capacity of regenerate …