Progesterone is commonly considered as a female reproductive hormone and is well-known
for its role in pregnancy. It is less well appreciated that progesterone and its metabolite …

This chapter provides an overview of neurosteroids, especially their impact on the brain, sex
differences and their therapeutic potentials. Neurosteroids are synthesized within the brain …

Alcoholism is a debilitating disorder for the individual and very costly for society. A major
goal of alcohol research is to understand the neural underpinnings associated with the …

The past decade has brought many advances in our understanding of GABA A receptor-
mediated ethanol action in the central nervous system. We now know that specific GABA A …

ABSTRACT Introduction 5α-reductase inhibitors (5α-RIs), finasteride and dutasteride, have
been approved for treatment of lower urinary tract symptoms, due to benign prostatic …

Steroids influence neuronal function through binding to cognate intracellular receptors
which may act as transcription factors in the regulation of gene expression. In addition …

Lösel, Ralf M., Elisabeth Falkenstein, Martin Feuring, Armin Schultz, Hanns-Christian
Tillmann, Karin Rossol-Haseroth, and Martin Wehling. Nongenomic Steroid Action …

Neurosteroids are key endogenous molecules in the brain that affect many neural functions.
We describe here recent advances in US National Institutes of Health (NIH)-sponsored and …

Nerve cells (ie, neurons) communicate via a combination of electrical and chemical signals.
Within the neuron, electrical signals driven by charged particles allow rapid conduction from …

Neuroactive steroids are endogenous neuromodulators synthesised in the brain that rapidly
alter neuronal excitability by binding to membrane receptors, in addition to the regulation of …