Hi-C is a genome-wide assay based on Chromosome Conformation Capture and high-
throughput sequencing to decipher 3D chromatin organization in the nucleus. However …

Raman spectrum is wealth of structural information, which can be used as molecular
fingerprint to identify compounds. There are relations between the intensities of Raman …

Recently, many literatures have proved that prior information and structure in many
application fields can be formulated as constraints on regression coefficients. Following …

Chromosomal aberrations, such as micronuclei (MN), have served as biomarkers of
genotoxic exposure and cancer risk. Guidelines for the process of scoring MN have been …

This paper presents a methodology, called ROBOUT, to identify outliers conditional on a
high-dimensional noisy information set. In particular, ROBOUT is able to identify …

Identifying the molecular modules that drive cancer progression can greatly deepen the
understanding of cancer mechanisms and provide useful information for targeted therapies …

In this paper, we propose a non-negative feature selection/feature grou** (nnFSG)
method for general sign-constrained high-dimensional regression problems that allows …

This paper presents a fast methodology, called ROBOUT, to identify outliers in a response
variable conditional on a set of linearly related predictors, retrieved from a large granular …

This dissertation focuses on the development and implementation of statistical methods for
high-dimensional and/or complex data, with an emphasis on $ p $, the number of …

Coronal mass ejections are colossal bursts of magnetic field and plasma from the Sun.
These eruptions can have disastrous effects on Earth's telecommunication systems and …