Antibiotics have always been considered one of the wonder discoveries of the 20th century.
This is true, but the real wonder is the rise of antibiotic resistance in hospitals, communities …

Integrons are versatile gene acquisition systems commonly found in bacterial genomes.
They are ancient elements that are a hot spot for genomic complexity, generating phenotypic …

▪ Abstract Uncultured microorganisms comprise the majority of the planet's biological
diversity. Microorganisms represent two of the three domains of life and contain vast …

Integrons are assembly platforms—DNA elements that acquire open reading frames
embedded in exogenous gene cassettes and convert them to functional genes by ensuring …

Antibiotics were one of the great discoveries of the 20th century. However, resistance
appeared even in the earliest years of the antibiotic era. Antibiotic resistance continues to …

Gene cassettes are small mobile elements, consisting of little more than a single gene and
recombination site, which are captured by larger elements called integrons. Several …

John Dupré explores recent revolutionary developments in biology and considers their
relevance for our understanding of human nature and human society. Epigenetics and …

Integrons recombine gene arrays and favor the spread of antibiotic resistance. Their broader
roles in bacterial adaptation remain mysterious, partly due to lack of computational tools. We …

Pseudomonas aeruginosa strains exhibit significant variability in pathogenicity and
ecological flexibility. Such interstrain differences reflect the dynamic nature of the P …

Antibiotic resistance is one of the few examples of evolution that can be addressed
experimentally. The present review analyses this resistance, focusing on the networks that …