Lactate dehydrogenase (LDH) is one of the crucial enzymes in aerobic glycolysis, catalyzing
the last step of glycolysis, ie. the conversion of pyruvate to lactate. Most cancer cells are …

Melanoma is the most lethal skin cancer that originates from the malignant transformation of
melanocytes. Although melanoma has long been regarded as a cancerous malignancy with …

Immune evasion and metabolic reprogramming are two fundamental hallmarks of cancer.
Interestingly, lactate closely links them together. However, lactate has long been recognized …

The Warburg effect, characterized by the preferential conversion of glucose to lactate even
in the presence of oxygen and functional mitochondria, is a prominent metabolic hallmark of …

Hypoxia, low oxygen (O2) level, is a hallmark of solid cancers, especially hepatocellular
carcinoma (HCC), one of the most common and fatal cancers worldwide. Hypoxia …

Tumor cells must generate sufficient ATP and biosynthetic precursors in order to maintain
cell proliferation requirements. Otto Warburg showed that tumor cells uptake high amounts …

Triple-negative breast cancer (TNBC) remains an unmet medical challenge. We investigated
metabolic dysregulation in TNBCs by using our multi-omics database (n= 465, the largest to …

Simple Summary The role of lactate in cancer described by Otto Warburg in 1927 states that
cancer cells uptake high amount of glucose with a marked increase in lactate production …

Metabolite lactic acid has always been regarded as a metabolic by-product rather than a
bioactive molecule. Recently, this view has changed since it was discovered that lactic acid …

Tumor-derived lactic acid inhibits T and natural killer (NK) cell function and, thereby, tumor
immunosurveillance. Here, we report that melanoma patients with high expression of …