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Designing artificial metalloenzymes by tuning of the environment beyond the primary coordination sphere
Metalloenzymes catalyze a variety of reactions using a limited number of natural amino
acids and metallocofactors. Therefore, the environment beyond the primary coordination …
acids and metallocofactors. Therefore, the environment beyond the primary coordination …
Gas tunnel engineering of prolyl hydroxylase reprograms hypoxia signaling in cells
P Windsor, H Ouyang, JA G. da Costa… - Angewandte Chemie …, 2024 - Wiley Online Library
Cells have evolved intricate mechanisms for recognizing and responding to changes in
oxygen (O2) concentrations. Here, we have reprogrammed cellular hypoxia (low O2) …
oxygen (O2) concentrations. Here, we have reprogrammed cellular hypoxia (low O2) …
Development of Nonheme {FeNO}7 Complexes Based on the Pyrococcus furiosus Rubredoxin for Red-Light-Controllable Nitric Oxide Release
S Lin, C He - Inorganic Chemistry, 2021 - ACS Publications
Nitric oxide (NO) is an essential biological messenger, contributing a significant role in a
diverse range of physiological processes. The light-controllable NO releasers are of great …
diverse range of physiological processes. The light-controllable NO releasers are of great …