Aging is a complex feature and involves loss of multiple functions and nonreversible
phenotypes. However, several studies suggest it is possible to protect against aging and …

Aging is a chronic, complicated process that leads to degenerative physical and biological
changes in living organisms. Aging is associated with permanent, gradual physiological …

To withstand physiological loading over a lifetime, human synovial joints are covered and
protected by articular cartilage, a layer of low-friction, load-bearing tissue. The unique …

Background: The increased risk of long-term osteoarthritis from concomitant injuries to the
menisci or cartilage after an anterior cruciate ligament (ACL) injury in adults is well …

Mechanical factors play a key role in regulating the development of cartilage degradation in
osteoarthritis. This study aimed to identify the influence of mechanical stress in cartilage and …

Osteoarthritis (OA) has historically been classified as 'primary'where no discernible cause
was evident and 'secondary'where a triggering factor was apparent. Irrespective of the …

Cells within cartilaginous tissues are mechanosensitive and thus require mechanical
loading for regulation of tissue homeostasis and metabolism. Mechanical loading plays …

The transfer of stress and strain signals between the extracellular matrix (ECM) and cells is
crucial for biochemical and biomechanical cues that are required for tissue morphogenesis …

Articular cartilage chondrocytes are responsible for the synthesis, maintenance, and
turnover of the extracellular matrix, metabolic processes that contribute to the mechanical …

Human adipose-derived mesenchymal stem cells (MSCs) were differentiated into
chondrogenic MSCs, and fibrin glue was used together to explore the feasibility of whether …