Terahertz spectroscopy as a method for investigation of hydration shells of biomolecules

NV Penkov - Biophysical Reviews, 2023 - Springer
The hydration of biomolecules is one of the fundamental processes underlying the
construction of living matter. The formation of the native conformation of most biomolecules …

Hydration dynamics in biological membranes: Emerging applications of terahertz spectroscopy

S Pal, A Chattopadhyay - The Journal of Physical Chemistry …, 2021 - ACS Publications
Water drives the spontaneous self-assembly of lipids and proteins into quasi two-
dimensional biological membranes that act as catalytic scaffolds for numerous processes …

Excipients do regulate phase separation in lysozyme and thus also its hydration

P Pyne, RK Mitra - The Journal of Physical Chemistry Letters, 2022 - ACS Publications
While the liquid–liquid phase separation (LLPS) process in proteins has been studied in
great detail, it has not been widely explored how the associated protein hydration changes …

A subtle interplay between hydrophilic and hydrophobic hydration governs butanol (de) mixing in water

S Chakraborty, P Pyne, RK Mitra, DD Mahanta - Chemical Physics Letters, 2022 - Elsevier
A possible molecular origin of the contorting water-solubility of butanol isomers lies in the
self-association propensity of alcohols as well as on the specific interaction between the …

Thermo-Resistive Phase Behavior of Trivalent Ion-Induced Microscopic Protein-Rich Phases: Correlating with Ion-Specific Protein Hydration

R Saha, RK Mitra - Langmuir, 2023 - ACS Publications
Proteins, in the presence of trivalent cations, exhibit intriguing phase behavior which is
contrasting compared to mono-and divalent cations. At room temperature (RT), trivalent …

Peculiarities of the dynamical hydration shell of native conformation protein using a bovine serum albumin example

NV Penkov - Applied Spectroscopy, 2024 - journals.sagepub.com
This paper describes an approach based on the method of terahertz time-domain
spectroscopy, which allows the analysis of dynamical hydration shells of proteins with a …

Sugar Molecules Inhibit Insulin Aggregation: A Decisive Role Being Played by the Protein Solvation Energetics

P Pyne, S Pyne, RK Mitra - The Journal of Physical Chemistry B, 2023 - ACS Publications
Insulin plays vital roles in controlling blood sugar level in the human body. However, it
sometimes aggregates during the storage, and its efficacy (on the treatment of diabetes II …