[HTML][HTML] limma powers differential expression analyses for RNA-sequencing and microarray studies
Abstract limma is an R/Bioconductor software package that provides an integrated solution
for analysing data from gene expression experiments. It contains rich features for handling …
for analysing data from gene expression experiments. It contains rich features for handling …
Statistical analysis of high-dimensional biomedical data: a gentle introduction to analytical goals, common approaches and challenges
Background In high-dimensional data (HDD) settings, the number of variables associated
with each observation is very large. Prominent examples of HDD in biomedical research …
with each observation is very large. Prominent examples of HDD in biomedical research …
TOX reinforces the phenotype and longevity of exhausted T cells in chronic viral infection
Cytotoxic T cells are essential mediators of protective immunity to viral infection and
malignant tumours and are a key target of immunotherapy approaches. However, prolonged …
malignant tumours and are a key target of immunotherapy approaches. However, prolonged …
Peripherally derived macrophages can engraft the brain independent of irradiation and maintain an identity distinct from microglia
Peripherally derived macrophages infiltrate the brain after bone marrow transplantation and
during central nervous system (CNS) inflammation. It was initially suggested that these …
during central nervous system (CNS) inflammation. It was initially suggested that these …
Foxp3+ T cells expressing RORγt represent a stable regulatory T-cell effector lineage with enhanced suppressive capacity during intestinal inflammation
Foxp3 (forkhead box P3 transcription factor)-expressing regulatory T cells (Tregs) are
essential for immunological tolerance, best illustrated by uncontrolled effector T-cell …
essential for immunological tolerance, best illustrated by uncontrolled effector T-cell …
TMTpro: design, synthesis, and initial evaluation of a proline-based isobaric 16-plex tandem mass tag reagent set
A Thompson, N Wölmer, S Koncarevic… - Analytical …, 2019 - ACS Publications
The design and synthesis of a proline-based reporter isobaric Tandem Mass Tag structure
(TMTpro) is presented. An analysis is made of the performance of the new TMTpro tags in …
(TMTpro) is presented. An analysis is made of the performance of the new TMTpro tags in …
T-bet and Eomes instruct the development of two distinct natural killer cell lineages in the liver and in the bone marrow
C Daussy, F Faure, K Mayol, S Viel… - Journal of Experimental …, 2014 - rupress.org
Trail+ DX5− Eomes− natural killer (NK) cells arise in the mouse fetal liver and persist in the
adult liver. Their relationships with Trail− DX5+ NK cells remain controversial. We generated …
adult liver. Their relationships with Trail− DX5+ NK cells remain controversial. We generated …
Optimizing the noise versus bias trade-off for Illumina whole genome expression BeadChips
Five strategies for pre-processing intensities from Illumina expression BeadChips are
assessed from the point of view of precision and bias. The strategies include a popular …
assessed from the point of view of precision and bias. The strategies include a popular …
Control of Reproductive Floral Organ Identity Specification in Arabidopsis by the C Function Regulator AGAMOUS
The floral organ identity factor AGAMOUS (AG) is a key regulator of Arabidopsis thaliana
flower development, where it is involved in the formation of the reproductive floral organs as …
flower development, where it is involved in the formation of the reproductive floral organs as …
Gene set analysis methods: a systematic comparison
Background Gene set analysis is a valuable tool to summarize high-dimensional gene
expression data in terms of biologically relevant sets. This is an active area of research and …
expression data in terms of biologically relevant sets. This is an active area of research and …