Tumour treating fields therapy for glioblastoma: current advances and future directions
O Rominiyi, A Vanderlinden, SJ Clenton… - British journal of …, 2021 - nature.com
Glioblastoma multiforme (GBM) is the most common primary brain tumour in adults and
continues to portend poor survival, despite multimodal treatment using surgery and …
continues to portend poor survival, despite multimodal treatment using surgery and …
DNA damage: from threat to treatment
A Carusillo, C Mussolino - Cells, 2020 - mdpi.com
DNA is the source of genetic information, and preserving its integrity is essential in order to
sustain life. The genome is continuously threatened by different types of DNA lesions, such …
sustain life. The genome is continuously threatened by different types of DNA lesions, such …
Phase separation properties of RPA combine high-affinity ssDNA binding with dynamic condensate functions at telomeres
RPA has been shown to protect single-stranded DNA (ssDNA) intermediates from instability
and breakage. RPA binds ssDNA with sub-nanomolar affinity, yet dynamic turnover is …
and breakage. RPA binds ssDNA with sub-nanomolar affinity, yet dynamic turnover is …
[HTML][HTML] Properties and behavior of carbon nanomaterials when interfacing neuronal cells: How far have we come?
In the last two decades, an increasing amount of studies have investigated the use of
components based on carbon-(nano) materials in the engineering of neural interfaces, to …
components based on carbon-(nano) materials in the engineering of neural interfaces, to …
The human Shu complex promotes RAD51 activity by modulating RPA dynamics on ssDNA
Templated DNA repair that occurs during homologous recombination and replication stress
relies on RAD51. RAD51 activity is positively regulated by BRCA2 and the RAD51 paralogs …
relies on RAD51. RAD51 activity is positively regulated by BRCA2 and the RAD51 paralogs …
Replication protein A: a multifunctional protein with roles in DNA replication, repair and beyond
R Dueva, G Iliakis - NAR cancer, 2020 - academic.oup.com
Single-stranded DNA (ssDNA) forms continuously during DNA replication and is an
important intermediate during recombination-mediated repair of damaged DNA. Replication …
important intermediate during recombination-mediated repair of damaged DNA. Replication …
Dynamic elements of replication protein A at the crossroads of DNA replication, recombination, and repair
The heterotrimeric eukaryotic Replication protein A (RPA) is a master regulator of numerous
DNA metabolic processes. For a long time, it has been viewed as an inert protector of …
DNA metabolic processes. For a long time, it has been viewed as an inert protector of …
ssDNA accessibility of Rad51 is regulated by orchestrating multiple RPA dynamics
The eukaryotic single-stranded DNA (ssDNA)-binding protein Replication Protein A (RPA)
plays a crucial role in various DNA metabolic pathways, including DNA replication and …
plays a crucial role in various DNA metabolic pathways, including DNA replication and …
Role of Rad51 and DNA repair in cancer: A molecular perspective
The maintenance of genome integrity is essential for any organism survival and for the
inheritance of traits to offspring. To the purpose, cells have developed a complex DNA repair …
inheritance of traits to offspring. To the purpose, cells have developed a complex DNA repair …
Identification of a small-molecule inhibitor that selectively blocks DNA-binding by Trypanosoma brucei replication protein A1
Abstract Replication Protein A (RPA) is a broadly conserved complex comprised of the
RPA1, 2 and 3 subunits. RPA protects the exposed single-stranded DNA (ssDNA) during …
RPA1, 2 and 3 subunits. RPA protects the exposed single-stranded DNA (ssDNA) during …