Rho GTPases regulate cytoskeletal and cell adhesion dynamics and thereby coordinate a
wide range of cellular processes, including cell migration, cell polarity and cell cycle …

The'invisible hand'is a term originally coined by Adam Smith in The Theory of Moral
Sentiments to describe the forces of self-interest, competition and supply and demand that …

Asymmetric cell division, which includes cell polarization and cytokinesis, is essential for
generating cell diversity during development. The budding yeast Saccharomyces cerevisiae …

Dynamic patterning of specific proteins is essential for the spatio-temporal regulation of
many important intracellular processes in prokaryotes, eukaryotes and multicellular …

Many cells undergo symmetry-breaking polarization toward a randomly oriented" front" in
the absence of spatial cues. In budding yeast, such polarization involves a positive feedback …

Numerous studies have shown that oxidative stress resulting from an imbalance between
the production of free radicals and their neutralization by antioxidant enzymes is one of the …

Mathematical modeling has been instrumental in identifying common principles of cell
polarity across diverse systems. These principles include positive feedback loops that are …

Studies of the processes leading to the construction of a bud and its separation from the
mother cell in Saccharomyces cerevisiae have provided foundational paradigms for the …

Cdc42, a member of the Rho family of GTPases, has been shown to play a role in cell
adhesion, cytoskeletal arrangement, phagocytosis and cell motility and migration, in addition …

Cell polarity is typically oriented by external cues such as cell–cell contacts,
chemoattractants, or morphogen gradients. In the absence of such cues, however, many …