Purines and their derivatives, most notably adenosine and ATP, are the key molecules
controlling intracellular energy homoeostasis and nucleotide synthesis. Besides, these …

Hypoxia inhibits the tricarboxylic acid (TCA) cycle and leaves glycolysis as the primary
metabolic pathway responsible for converting glucose into usable energy. However, the …

The metabolic adaptation of eukaryotic cells to hypoxia involves increasing dependence
upon glycolytic adenosine triphosphate (ATP) production, an event with consequences for …

The human pathogenic trypanosomatid species collectively called the “TriTryp parasites”–
Trypanosoma brucei, Trypanosoma cruzi and Leishmania spp.–have complex life cycles …

Metabolites are critical products and mediators of cellular and tissue function, and key
signals in cell-to-cell, organ-to-organ and cross-organism communication. Many of these …

Peroxisomes are vital metabolic organelles that import their lumenal (matrix) enzymes from
the cytosol using mobile receptors. Surprisingly, the receptors can even import folded …

Phosphoglycerate kinase (PGK) is a glycolytic enzyme that is well conserved among the
three domains of life. PGK is usually a monomeric enzyme of about 45 kDa that catalyses …

Protozoan parasites represent a significant risk for public health worldwide, afflicting
particularly people in more vulnerable categories and cause large morbidity and heavy …

Purines are ancient metabolites with established and emerging metabolic and non-
metabolic signaling attributes. The expression of purine metabolism-related genes is …

The molecular repertoire of Trypanosoma cruzi effects its virulence and impacts the clinical
course of the resulting Chagas disease. This study aimed to determine the mechanism …