Stem cells are not only units of biological organization, a clonal level are restricted to give
rise to T lymphocytes, responsible for the development and the regeneration B lymphocytes …

Hematopoiesis–the process by which blood cells are formed–has been studied intensely for
over a century using a variety of model systems. There is conservation of the overall …

The adult hematopoietic system of mammals is a dynamic hierarchy of cells with the
hematopoietic stem cell at its foundation. During embryonic development, the source and …

The zebrafish (Danio rerio) is a powerful model organism for the study of vertebrate biology,
being well suited to both developmental and genetic analysis. Large-scale genetic screens …

In the zebrafish embryo, the only known site of hemopoieisis is an intra-embryonic blood
island at the junction between trunk and tail that gives rise to erythroid cells. Using video …

Information on the ontogeny of the fish immune system is largely restricted to a few species
of teleosts (eg, rainbow trout, catfish, zebrafish, sea bass) and has previously focused on …

Platelets are the second most abundant cell type in blood and are essential for maintaining
haemostasis. Their count and volume are tightly controlled within narrow physiological …

Hematopoiesis is a complex process with a variety of different signaling pathways
influencing every step of blood cell formation from the earliest precursors to final …

Progressive advances using zebrafish as a model organism have provided hematologists
with an additional genetic system to study blood cell formation and hematological …

Since its debut in the biomedical research fields in 1981, zebrafish have been used as a
vertebrate model organism in more than 40,000 biomedical research studies. Especially …