Immune response following traumatic spinal cord injury: Pathophysiology and therapies

RC Sterner, RM Sterner - Frontiers in immunology, 2023 - frontiersin.org
Traumatic spinal cord injury (SCI) is a devastating condition that is often associated with
significant loss of function and/or permanent disability. The pathophysiology of SCI is …

Progression in translational research on spinal cord injury based on microenvironment imbalance

B Fan, Z Wei, S Feng - Bone research, 2022 - nature.com
Spinal cord injury (SCI) leads to loss of motor and sensory function below the injury level
and imposes a considerable burden on patients, families, and society. Repair of the injured …

Programmed cell death in spinal cord injury pathogenesis and therapy

Z Shi, S Yuan, L Shi, J Li, G Ning, X Kong… - Cell …, 2021 - Wiley Online Library
Spinal cord injury (SCI) always leads to functional deterioration due to a series of processes
including cell death. In recent years, programmed cell death (PCD) is considered to be a …

Acute spinal cord injury: Pathophysiology and pharmacological intervention

Y Zhang, A Al Mamun, Y Yuan… - Molecular …, 2021 - spandidos-publications.com
Spinal cord injury (SCI) is one of the most debilitating of all the traumatic conditions that
afflict individuals. For a number of years, extensive studies have been conducted to clarify …

Growth factors-based therapeutic strategies and their underlying signaling mechanisms for peripheral nerve regeneration

R Li, D Li, H Zhang, J Wang, X Li, J **ao - Acta Pharmacologica Sinica, 2020 - nature.com
Peripheral nerve injury (PNI), one of the most common concerns following trauma, can result
in a significant loss of sensory or motor function. Restoration of the injured nerves requires a …

Spinal cord injury: pathophysiology, treatment strategies, associated challenges, and future implications

K Venkatesh, SK Ghosh, M Mullick… - Cell and tissue …, 2019 - Springer
Axonal regeneration and formation of tripartite (axo-glial) junctions at damaged sites is a
prerequisite for early repair of injured spinal cord. Transplantation of stem cells at such sites …

Therapeutic repair for spinal cord injury: combinatory approaches to address a multifaceted problem

JM Griffin, F Bradke - EMBO molecular medicine, 2020 - embopress.org
The recent years saw the advent of promising preclinical strategies that combat the
devastating effects of a spinal cord injury (SCI) that are progressing towards clinical trials …

Biomimetic peptide nanonets: exploiting bacterial entrapment and macrophage rerousing for combatting infections

N Gao, P Bai, C Fang, W Wu, C Bi, J Wang, A Shan - ACS nano, 2024 - ACS Publications
The alarming rise in global antimicrobial resistance underscores the urgent need for
effective antibacterial drugs. Drawing inspiration from the bacterial-entrapment mechanism …

Strategies and prospects of effective neural circuits reconstruction after spinal cord injury

B Yang, F Zhang, F Cheng, L Ying, C Wang, K Shi… - Cell Death & …, 2020 - nature.com
Due to the disconnection of surviving neural elements after spinal cord injury (SCI), such
patients had to suffer irreversible loss of motor or sensory function, and thereafter enormous …

Astrocytic YAP promotes the formation of glia scars and neural regeneration after spinal cord injury

C **e, X Shen, X Xu, H Liu, F Li, S Lu, Z Gao… - Journal of …, 2020 - jneurosci.org
Yes-associated protein (YAP) transcriptional coactivator is negatively regulated by the Hippo
pathway and functions in controlling the size of multiple organs, such as liver during …