This perspective describes predictive processing as a computational framework for
understanding cortical function in the context of emerging evidence, with a focus on sensory …

Highlights•New generations of recording and computing technologies have enabled
neuroscience at the level of the neural population.•Landmark scientific findings suggest the …

Animals readily execute learned behaviors in a consistent manner over long periods of time,
and yet no equally stable neural correlate has been demonstrated. How does the cortex …

The motor cortex controls skilled arm movement by sending temporal patterns of activity to
lower motor centres. Local cortical dynamics are thought to shape these patterns throughout …

Populations of cortical neurons flexibly perform different functions; for the primary motor
cortex (M1) this means a rich repertoire of motor behaviors. We investigate the flexibility of …

Severe spinal cord contusions interrupt nearly all brain projections to lumbar circuits
producing leg movement. Failure of these projections to reorganize leads to permanent …

Primate motor cortex projects to spinal interneurons and motoneurons, suggesting that
motor cortex activity may be dominated by muscle-like commands. Observations during …

Although we are continuously bombarded with visual input, only a fraction of incoming visual
events is perceived, remembered or acted on. The neural underpinnings of various forms of …

The neural mechanisms that generate an extensible library of motor motifs and flexibly string
them into arbitrary sequences are unclear. We developed a model in which inhibitory basal …

Advances in neural recording present increasing opportunities to study neural activity in
unprecedented detail. Latent variable models (LVMs) are promising tools for analyzing this …