Hypoxia is a common feature of solid tumors, and develops because of the rapid growth of
the tumor that outstrips the oxygen supply, and impaired blood flow due to the formation of …

E-cadherin is a single-pass transmembrane protein that mediates homophilic cell–cell
interactions. Tumour progression is often associated with the loss of E-cadherin function and …

The analysis of histopathology images with artificial intelligence aims to enable clinical
decision support systems and precision medicine. The success of such applications …

Computational pathology uses artificial intelligence to enable precision medicine and
decision support systems through the analysis of whole slide images. It has the potential to …

Cadherins are homophilic adhesion molecules with important functions in cell-cell adhesion,
tissue morphogenesis, and cancer. In epithelial cells, E-cadherin accumulates at areas of …

Adherens junctions and Tight junctions comprise two modes of cell–cell adhesion that
provide different functions. Both junctional complexes are proposed to associate with the …

Tissue morphogenesis during development is dependent on activities of the cadherin family
of cell–cell adhesion proteins that includes classical cadherins, protocadherins, and atypical …

The cadherin molecules at adherens junctions have multiple isoforms. Cadherin isoform
switching (cadherin switching) occurs during normal developmental processes to allow cell …

E-cadherin-based cell-cell adhesions are dynamically and locally regulated in many
essential processes, including embryogenesis, wound healing and tissue organization, with …

Invasion, the hallmark of malignancy, consists in the translocation of tumour cells from the
initial neoplastic focus into neighbouring host tissues, and also allows tumour cells to …