▪ Abstract The Wiskott-Aldrich Syndrome (WAS) is a rare X-linked primary immunodeficiency
that is characterized by recurrent infections, hematopoietic malignancies, eczema, and …

All eukaryotic cells need to reorganize their actin cytoskeleton to change shape, divide,
move, and take up nutrients for survival. The Wiskott-Aldrich syndrome protein (WASP) and …

Wiskott–Aldrich syndrome (WAS) is an X-linked primary immunodeficiency with a median
survival below the age of 20 due to infections, severe hemorrhage, and lymphomas …

Gene therapy has been proposed as a potential treatment for Wiskott–Aldrich syndrome
(WAS), a severe primary immune deficiency characterized by multiple hematopoietic …

Wiskott–Aldrich syndrome (WAS) is an immune deficiency with thrombopenia resulting from
mutations in the WASP gene. This gene normally encodes the Wiskott–Aldrich syndrome …

Abstract The immunodeficiency disorder Wiskott-Aldrich syndrome (WAS) leads to life-
threatening hematopoietic cell dysfunction. We used WAS protein (WASp)–deficient mice to …

Wiskott–Aldrich Syndrome (WAS) is a life-threatening X-linked disease characterized by
immunodeficiency, thrombocytopenia, autoimmunity, and malignancies. Gene therapy could …

Ets-1 is the prototype of the family of ETS transcription factors. In human tumors, Ets-1 is
expressed in endothelial cells and fibroblasts of the tumor stroma and is proposed to play a …

The most frequent chromosomal translocations in pediatric acute myeloid leukemia affect
the 11q23 locus and give rise to mixed lineage leukemia (MLL) fusion genes, MLL-AF9 …

Publisher Summary This chapter discusses primary immunodeficiency mutation databases.
Primary immunodeficiencies are intrinsic defects of immune systems. Mutations in a large …