Drug target interaction is a prominent research area in the field of drug discovery. It refers to
the recognition of interactions between chemical compounds and the protein targets in the …

Tight junctions are the most apical component of the epithelial junctional complex and are
crucial for the formation and functioning of epithelial and endothelial barriers. They regulate …

Statins inhibit HMG-CoA reductase, a key enzyme in cholesterol synthesis, and are widely
used to treat hypercholesterolemia. These drugs can lead to a number of side effects in …

Skeletal muscle is a highly adaptive tissue, capable of altering muscle fiber size, functional
capacity and metabolism in response to physiological stimuli. However, pathological …

Testicular germ cell tumors (TGCT) have been expected to have a strong underlying genetic
component. We conducted a genome-wide scan among 277 TGCT cases and 919 controls …

Tight junctions are important for the permeability properties of epithelial and endothelial
barriers as they restrict diffusion along the paracellular space. Recent observations have …

Kit is a receptor tyrosine kinase (RTK) that binds stem cell factor. This receptor ligand
combination is important for normal hematopoiesis, as well as pigmentation, gut function …

AKT kinases are attractive targets for small molecule drug discovery because of their key
role in tumor cell survival/proliferation and their overexpression/activation in many human …

A subset of gastrointestinal stromal tumors (GISTs) lack gain-of-function mutations in c-KIT
and PDGFR α. These so-called wild-type (WT) GISTs tend to be less responsive to imatinib …

Sprouty proteins are evolutionarily conserved modulators of MAPK/ERK pathway. Through
interacting with an increasing number of effectors, mediators, and regulators with ultimate …