CXCL1 is one of the most important chemokines, part of a group of chemotactic cytokines
involved in the development of many inflammatory diseases. It activates CXCR2 and, at high …

Immune checkpoint inhibitors (ICIs) are starting to transform the treatment for patients with
advanced cancer. The extensive application of these antibodies for various cancer obtains …

Abstract Background Ibrutinib is a Bruton's tyrosine kinase (BTK) and interleukin-2-inducible
kinase (ITK) inhibitor used for treating chronic lymphocytic leukaemia (CLL) and other …

Cancers of the oral cavity remain the sixth most diagnosed cancer worldwide, with high rates
of recurrence and mortality. We determined the role of STAT1 during oral carcinogenesis …

CXC motif chemokine ligand 1 (CXCL1) is a member of the CXC chemokine subfamily and a
ligand for CXCR2. Its main function in the immune system is the chemoattraction of …

Background Previous studies have revealed the critical role of transglutaminase 2 (TGM2)
as a potential therapeutic target in cancers, but the oncogenic roles and underlying …

Breast cancer (BC) is currently the most common malignant tumor of women in the world. At
present, the development of BC is accelerating and showing a younger trend, which may be …

Background: Aberrant activities of signal transducer and activator of transcription 1 (STAT1)
have been implicated in cancer development. However, the prognostic value of STAT1 …

Both angiogenesis and lncRNAs play crucial roles in the development and progression of
breast cancer. Considering the unknown association of angiogenesis and lncRNAs in breast …

Myeloid-derived suppressor cells (MDSCs) are a group of immunosuppressive cells that
play crucial roles in promoting tumor growth and protecting tumors from immune recognition …