Kinases have emerged as one of the most intensively pursued targets in current
pharmacological research, especially for cancer, due to their critical roles in cellular …

Members of the human epidermal growth factor receptor (HER) family, which includes HER1
(also known as EGFR), HER2, HER3 and HER4, have played a central role in regulating cell …

Human epidermal growth factor receptor 2 (HER2) and HER3 form a potent pro-oncogenic
heterocomplex,–upon binding of growth factor neuregulin-1β (NRG1β). The mechanism by …

Purpose Invasive lobular breast cancer (ILBC) is the second most common histologic
subtype after invasive ductal breast cancer (IDBC). Despite clinical and pathologic …

BACKGROUND In contrast to lung cancer, few precision treatments are available for
colorectal cancer (CRC). One rapidly emerging treatment target in CRC is ERBB2 (human …

Eph receptors, the largest subfamily of receptor tyrosine kinases, are linked with proliferative
disease, such as cancer, as a result of their deregulated expression or mutation. Unlike …

Pseudokinases are members of the protein kinase superfamily but signal primarily through
noncatalytic mechanisms. Many pseudokinases contribute to the pathologies of human …

Activating mutations in HER2 (ERBB2) drive the growth of a subset of breast and other
cancers and tend to co-occur with HER3 (ERBB3) missense mutations. The HER2 tyrosine …

Deregulated HER2 is a target of many approved cancer drugs. We analyzed 111,176 patient
tumors and identified recurrent mutations in HER2 transmembrane domain (TMD) and …

Protein kinases are known primarily for their ability to phosphorylate protein substrates,
which constitutes an essential biological process. Recently, compelling evidence has …