Messenger RNA (mRNA) is an emerging class of therapeutic agent for the prevention and
treatment of a wide range of diseases. The recent success of the two highly efficacious …

Abstract mRNA vaccines have emerged as a revolutionary tool to generate rapid and
precise immune responses against infectious diseases and cancers. Compared with …

Abstract mRNA therapeutics have emerged as powerful tools for cancer immunotherapy in
accordance with their superiority in expressing all sequence‐known proteins in vivo. In …

Unlocking the full potential of mRNA immunotherapy necessitates targeted delivery to
specific cell subsets in the spleen. Four‐component lipid nanoparticles (LNPs) utilized in …

Messenger RNA (mRNA) vaccine development for preventive and therapeutic applications
has evolved rapidly over the last decade. The mRVNA vaccine has proven therapeutic …

Polymers represent a promising therapeutic platform for extrahepatic messenger RNA
(mRNA) delivery but are hampered by low in vivo efficacy due to polyplex serum instability …

Delivery of nucleic acids with viral and synthetic vectors has pioneered genetic
nanomedicine. Four-component lipid nanoparticles (LNPs) consisting of ionizable lipids …

Ionizable lipid nanoparticles (LNPs) are seeing widespread use in mRNA delivery, notably
in SARS-CoV-2 mRNA vaccines. However, the expansion of mRNA therapies beyond …

The development of lipid nanoparticles (LNPs) has enabled a successful clinical application
of mRNA vaccines. However, disclosure of design principles for the core component …

Among the few available mRNA delivery vehicles, lipid nanoparticles (LNPs) are the most
clinically advanced but they require cumbersome four components and suffer from …