Tumor-secreted extracellular vesicles (EVs) are critical mediators of intercellular
communication between tumor cells and stromal cells in local and distant …

Despite all of the progress in understanding its molecular biology and pathogenesis,
glioblastoma (GBM) is one of the most aggressive types of cancers, and without an efficient …

Recent advances in genomic technology have led to a better understanding of key
molecular alterations that underlie glioblastoma (GBM). The current WHO-based …

Extracellular vesicles (EVs) such as exosomes are released by all living cells and contain
diverse bioactive molecules, including nucleic acids, proteins, lipids, and metabolites …

Glioblastoma (GBM) is a primary neuroepithelial tumor of the central nervous system,
characterized by an extremely aggressive clinical phenotype. Patients with GBM have a …

Exosomes and other extracellular vesicles (commonly referred to as EVs) have generated a
lot of attention for their potential applications in both diagnostics and therapeutics. The …

The epidermal growth factor receptor (EGFR) is one of most potent oncogenes that are
commonly altered in cancers. As a receptor tyrosine kinase, EGFR's kinase activity has been …

Glioblastoma tumour cells release microvesicles (exosomes) containing mRNA, miRNA and
angiogenic proteins. These microvesicles are taken up by normal host cells, such as brain …

Background The epidermal growth factor receptor variant III deletion mutation, EGFRvIII, is
expressed in∼ 30% of primary glioblastoma and linked to poor long-term survival …

Malignant gliomas, the most common type of primary brain tumor in adults, are associated
with disproportionate cancer-related morbidity and mortality. Recently, there have been …