Joint pain is the hallmark symptom of osteoarthritis (OA) and the main reason for patients to
seek medical assistance. OA pain greatly contributes to functional limitations of joints and …

Neuropathic pain, caused by a lesion or disease affecting the somatosensory system, affects
between 3 and 17% of the general population. The treatment of neuropathic pain is …

Peripheral nerve injuries induce a pronounced immune reaction within the spinal cord,
largely governed by microglia activation in both the dorsal and ventral horns. The …

The persistence of increased excitability and spontaneous activity in injured peripheral
neurons is imperative for the development and persistence of many forms of neuropathic …

Chronic low back pain caused by intervertebral disc (IVD) degeneration, also termed chronic
discogenic low back pain (CD‐LBP), is one of the most prevalent musculoskeletal diseases …

Neuropathic pain can result from injury to, or disease of the nervous system. It is notoriously
difficult to treat. Peripheral nerve injury promotes Schwann cell activation and invasion of …

Emerging studies have demonstrated spinal microglia play a critical role in central
sensitization and contribute to chronic pain. Although several mediators that contribute to …

Neuropathic pain (NPP) is a common syndrome associated with most forms of cancer, which
poses a serious threat to human health. NPP may persist even after the nociceptive …

Neuropathic pain is one of the most debilitating forms of chronic pain, resulting from an
injury or disease of the somatosensory nervous system, which induces abnormal painful …

In males but not in females, brain derived neurotrophic factor (BDNF) plays an obligatory
role in the onset and maintenance of neuropathic pain. Afferent terminals of injured …