Two different tumour-necrosis factors (TNFs), first isolated in 1984, were found to be
cytotoxic to tumour cells and to induce tumour regression in mice. Research during the past …

Natural killer (NK) cells, the large granular lymphocytes differentiated from the common
lymphoid progenitors, were discovered in early 1970's. They are members of innate …

Background: Rheumatoid arthritis is a chronic disabling disease characterized by chronic
inflammation, articular cartilage destruction, and reduced bone mass. Multiple studies have …

Obesity is traditionally viewed to be beneficial to bone health because of well-established
positive effect of mechanical loading conferred by body weight on bone formation, despite …

TNF-induced receptor activator NF-κB ligand (RANKL) synthesis by bone marrow stromal
cells is a fundamental component of inflammatory osteolysis. We found that this process was …

The detailed cellular and molecular mechanisms leading to joint destruction in rheumatoid
arthritis, a disease driven by proinflammatory cytokines, are still unknown. To address the …

Proinflammatory cytokines are infamous for their catabolic effects on tissues and joints in
both inflammatory diseases and following the implantation of biomedical devices. However …

Natural killer (NK) cells can be swiftly mobilized by danger signals and are among the
earliest arrivals at target organs of disease. However, the role of NK cells in mounting …

Bone destruction is a pathological hallmark of several chronic inflammatory diseases,
including rheumatoid arthritis and periodontitis. Inflammation-induced bone loss of this sort …

Osteoporosis is substantially an age-related condition characterized by low bone mass and
increased bone fragility, putting the patients at risk of fractures, which are major causes of …