ADP-ribosylation from molecular mechanisms to therapeutic implications
ADP-ribosylation is a ubiquitous modification of biomolecules, including proteins and
nucleic acids, that regulates various cellular functions in all kingdoms of life. The recent …
nucleic acids, that regulates various cellular functions in all kingdoms of life. The recent …
Roles for macrophage-polarizing interleukins in cancer immunity and immunotherapy
K Mortezaee, J Majidpoor - Cellular Oncology, 2022 - Springer
Macrophages are the most abundant and one of the most critical cells of tumor immunity.
They provide a bridge between innate and adaptive immunity through releasing cytokines …
They provide a bridge between innate and adaptive immunity through releasing cytokines …
PARP14 is a PARP with both ADP-ribosyl transferase and hydrolase activities
N Đukić, Ø Strømland, JD Elsborg, D Munnur, K Zhu… - Science …, 2023 - science.org
PARP14 is a mono–ADP-ribosyl transferase involved in the control of immunity,
transcription, and DNA replication stress management. However, little is known about the …
transcription, and DNA replication stress management. However, little is known about the …
ADP‐ribosyltransferases, an update on function and nomenclature
ADP‐ribosylation, a modification of proteins, nucleic acids, and metabolites, confers broad
functions, including roles in stress responses elicited, for example, by DNA damage and …
functions, including roles in stress responses elicited, for example, by DNA damage and …
PARP14 and PARP9/DTX3L regulate interferon-induced ADP-ribosylation
PARP-catalysed ADP-ribosylation (ADPr) is important in regulating various cellular
pathways. Until recently, PARP-dependent mono-ADP-ribosylation has been poorly …
pathways. Until recently, PARP-dependent mono-ADP-ribosylation has been poorly …
PARP14 inhibition restores PD-1 immune checkpoint inhibitor response following IFNγ-driven acquired resistance in preclinical cancer models
CW Wong, C Evangelou, KN Sefton, R Leshem… - Nature …, 2023 - nature.com
Resistance mechanisms to immune checkpoint blockade therapy (ICBT) limit its response
duration and magnitude. Paradoxically, Interferon γ (IFNγ), a key cytokine for cellular …
duration and magnitude. Paradoxically, Interferon γ (IFNγ), a key cytokine for cellular …
The KU-PARP14 axis differentially regulates DNA resection at stalled replication forks by MRE11 and EXO1
A Dhoonmoon, CM Nicolae, GL Moldovan - Nature communications, 2022 - nature.com
Suppression of nascent DNA degradation has emerged as an essential role of the BRCA
pathway in genome protection. In BRCA-deficient cells, the MRE11 nuclease is responsible …
pathway in genome protection. In BRCA-deficient cells, the MRE11 nuclease is responsible …
Beyond PARP1: the potential of other members of the poly (ADP-Ribose) polymerase family in DNA repair and cancer therapeutics
The proteins within the Poly-ADP Ribose Polymerase (PARP) family encompass a diverse
and integral set of cellular functions. PARP1 and PARP2 have been extensively studied for …
and integral set of cellular functions. PARP1 and PARP2 have been extensively studied for …
Immunomodulatory roles of PARPs: Sha** the tumor microenvironment, one ADP-ribose at a time
PARPs encompass a small yet pervasive group of 17 enzymes that catalyze a post-
translational modification known as ADP-ribosylation. PARP1, the founding member, has …
translational modification known as ADP-ribosylation. PARP1, the founding member, has …
Medicinal chemistry perspective on targeting mono-ADP-ribosylating PARPs with small molecules
MG Nizi, MM Maksimainen, L Lehtio… - Journal of Medicinal …, 2022 - ACS Publications
Major advances have recently defined functions for human mono-ADP-ribosylating PARP
enzymes (mono-ARTs), also opening up potential applications for targeting them to treat …
enzymes (mono-ARTs), also opening up potential applications for targeting them to treat …