Protein design aims to build novel proteins customized for specific purposes, thereby
holding the potential to tackle many environmental and biomedical problems. Recent …

Protein design aims to build new proteins from scratch thereby holding the potential to tackle
many environmental and biomedical problems. Recent progress in the field of natural …

Investigating the evolution of structural features in modern multidomain proteins helps to
understand their immense diversity and functional versatility. The class of periplasmic …

The design of proteins with tailored functions is of immense interest to biotechnology,
medicine, and the chemical industry. While protein design is rapidly evolving with the use of …

Periplasmic binding proteins (PBPs) are a class of proteins that participate in the cellular
transport of various ligands. They have been used as model systems to study mechanisms …

Modular assembly is a compelling pathway to create new proteins, a concept supported by
protein engineering and millennia of evolution. Natural evolution provided a repository of …

Life on earth is the result of the work of proteins, the cellular nanomachines that fold into
elaborated 3D structures to perform their functions. The ribosome synthesizes all the …

Modern proteins did not arise abruptly, as singular events, but rather over the course of at
least 3.5 billion years of evolution. Can machine learning teach us how this occurred? The …

In recent years, protein evolutionary studies have shifted from protein domains considered
as the basic evolutionary units to sub-domain sized fragments as the basis of diverse …