Coxsackievirus A16: epidemiology, diagnosis, and vaccine

Q Mao, Y Wang, X Yao, L Bian, X Wu… - Human vaccines & …, 2014 - Taylor & Francis
Coxsackievirus 16 (CA16) is one of the major pathogens associated with hand, foot, and
mouth disease (HFMD) in infants and young children. In recent years, CA16 and human …

Yeast-produced RBD-based recombinant protein vaccines elicit broadly neutralizing antibodies and durable protective immunity against SARS-CoV-2 infection

J Zang, Y Zhu, Y Zhou, C Gu, Y Yi, S Wang, S Xu, G Hu… - Cell Discovery, 2021 - nature.com
Massive production of efficacious SARS-CoV-2 vaccines is essential for controlling the
ongoing COVID-19 pandemic. We report here the preclinical development of yeast …

A combination vaccine comprising of inactivated enterovirus 71 and coxsackievirus A16 elicits balanced protective immunity against both viruses

Y Cai, Z Ku, Q Liu, Q Leng, Z Huang - Vaccine, 2014 - Elsevier
Abstract Enterovirus 71 (EV71) and coxsackievirus A16 (CA16) are the two major causative
agents of hand, foot and mouth disease (HFMD), which is an infectious disease frequently …

A virus-like particle-based tetravalent vaccine for hand, foot, and mouth disease elicits broad and balanced protective immunity

W Zhang, W Dai, C Zhang, Y Zhou… - Emerging Microbes & …, 2018 - Taylor & Francis
Hand, foot, and mouth disease (HFMD) is an infectious disease that mainly affects infants
and children, causing considerable morbidity and mortality worldwide. HFMD is commonly …

High-yield production of recombinant virus-like particles of enterovirus 71 in Pichia pastoris and their protective efficacy against oral viral challenge in mice

C Zhang, Z Ku, Q Liu, X Wang, T Chen, X Ye, D Li… - Vaccine, 2015 - Elsevier
Abstract Enterovirus 71 (EV71) is one of the major causative pathogens of hand, foot and
mouth disease (HFMD), which is highly prevalent in the Asia-Pacific regions. Severe HFMD …

A virus-like particle based bivalent vaccine confers dual protection against enterovirus 71 and coxsackievirus A16 infections in mice

Z Ku, Q Liu, X Ye, Y Cai, X Wang, J Shi, D Li, X **… - Vaccine, 2014 - Elsevier
Abstract Enterovirus 71 (EV71) and coxsackievirus A16 (CA16) are responsible for hand,
foot and mouth disease which has been prevalent in Asia-Pacific regions, causing …

Identification of conserved neutralizing linear epitopes within the VP1 protein of coxsackievirus A16

J Shi, X Huang, Q Liu, Z Huang - Vaccine, 2013 - Elsevier
Abstract Coxsackievirus A16 (CA16) is a major causative agent of hand, foot, and mouth
disease. Immunization with inactivated whole-virus or recombinant virus-like particles (VLP) …

A virus-like particle vaccine for coxsackievirus A16 potently elicits neutralizing antibodies that protect mice against lethal challenge

Q Liu, K Yan, Y Feng, X Huang, Z Ku, Y Cai, F Liu, J Shi… - Vaccine, 2012 - Elsevier
Coxsackievirus A16 (CVA16) is one of the main causative agents of hand, foot and mouth
disease (HFMD), which has been prevalent in the Asia-Pacific region over the last several …

Active immunization with a Coxsackievirus A16 experimental inactivated vaccine induces neutralizing antibodies and protects mice against lethal infection

Y Cai, Q Liu, X Huang, D Li, Z Ku, Y Zhang, Z Huang - Vaccine, 2013 - Elsevier
Coxsackievirus A16 (CA16) is one of the main pathogens that cause hand, foot and mouth
disease, which frequently occurs in young children. A small percentage of patients infected …

Neutralizing antibodies induced by recombinant virus-like particles of enterovirus 71 genotype C4 inhibit infection at pre-and post-attachment steps

Z Ku, X Ye, X Huang, Y Cai, Q Liu, Y Li, Z Su… - PLoS One, 2013 - journals.plos.org
Background Enterovirus 71 (EV71) is a major causative agent of hand, foot and mouth
disease, which has been prevalent in Asia–Pacific regions, causing significant morbidity and …