Cardiac fibrosis: the fibroblast awakens
Myocardial fibrosis is a significant global health problem associated with nearly all forms of
heart disease. Cardiac fibroblasts comprise an essential cell type in the heart that is …
heart disease. Cardiac fibroblasts comprise an essential cell type in the heart that is …
[HTML][HTML] Cardiovascular disease models: a game changing paradigm in drug discovery and screening
Cardiovascular disease is the leading cause of death worldwide. Although investment in
drug discovery and development has been sky-rocketing, the number of approved drugs has …
drug discovery and development has been sky-rocketing, the number of approved drugs has …
Getting to the heart of the matter: new insights into cardiac fibrosis
A Leask - Circulation research, 2015 - Am Heart Assoc
Fibrotic diseases are a significant global burden for which there are limited treatment
options. The effector cells of fibrosis are activated fibroblasts called myofibroblasts, a highly …
options. The effector cells of fibrosis are activated fibroblasts called myofibroblasts, a highly …
Single-cell RNA sequencing analysis reveals a crucial role for CTHRC1 (collagen triple helix repeat containing 1) cardiac fibroblasts after myocardial infarction
Background: Cardiac fibroblasts (CFs) have a central role in the ventricular remodeling
process associated with different types of fibrosis. Recent studies have shown that …
process associated with different types of fibrosis. Recent studies have shown that …
The role of Smad signaling cascades in cardiac fibrosis
Most myocardial pathologic conditions are associated with cardiac fibrosis, the expansion of
the cardiac interstitium through deposition of extracellular matrix (ECM) proteins. Although …
the cardiac interstitium through deposition of extracellular matrix (ECM) proteins. Although …
Biomarkers for the identification of cardiac fibroblast and myofibroblast cells
Experimental research has recognized the importance of cardiac fibroblast and
myofibroblast cells in heart repair and function. In a normal healthy heart, the cardiac …
myofibroblast cells in heart repair and function. In a normal healthy heart, the cardiac …
Transcriptional control of cardiac fibroblast plasticity
Cardiac fibroblasts help maintain the normal architecture of the healthy heart and are
responsible for scar formation and the healing response to pathological insults. Various …
responsible for scar formation and the healing response to pathological insults. Various …
The cytokines of pulmonary fibrosis: much learned, much more to learn
Organ fibrosis, the result of exaggerated, persistent, and often irreversible accumulation of
extracellular matrix, complicates numerous diseases in all organs and tissues and has …
extracellular matrix, complicates numerous diseases in all organs and tissues and has …
[HTML][HTML] Diverse origins and activation of fibroblasts in cardiac fibrosis
PK Aujla, Z Kassiri - Cellular signalling, 2021 - Elsevier
Cardiac fibroblasts (cFBs) have emerged as a heterogenous cell population. Fibroblasts are
considered the main cell source for synthesis of the extracellular matrix (ECM) and as such a …
considered the main cell source for synthesis of the extracellular matrix (ECM) and as such a …
Alamandine alleviated heart failure and fibrosis in myocardial infarction mice
K Zhao, T Xu, Y Mao, X Wu, D Hua, Y Sheng, P Li - Biology Direct, 2022 - Springer
Alamandine (Ala) is the newest identified peptide of the renin-angiotensin system and has
protective effect on myocyte hypertrophy. However, it is still unclear whether Ala can …
protective effect on myocyte hypertrophy. However, it is still unclear whether Ala can …