[HTML][HTML] Colon cancer and colorectal cancer: Prevention and treatment by potential natural products

MR Islam, S Akash, MM Rahman, FT Nowrin… - Chemico-biological …, 2022 - Elsevier
Colon cancer affects both men and women and is the world's second most significant cause
of cancer-related mortality. Colon cancer death rates have risen worldwide due to the …

Targeting apoptosis in cancer therapy

BA Carneiro, WS El-Deiry - Nature reviews Clinical oncology, 2020 - nature.com
For over three decades, a mainstay and goal of clinical oncology has been the development
of therapies promoting the effective elimination of cancer cells by apoptosis. This …

Overcoming cancer therapeutic bottleneck by drug repurposing

Z Zhang, L Zhou, N **e, EC Nice, T Zhang… - Signal transduction and …, 2020 - nature.com
Ever present hurdles for the discovery of new drugs for cancer therapy have necessitated
the development of the alternative strategy of drug repurposing, the development of old …

Protein glycosylation and tumor microenvironment alterations driving cancer hallmarks

A Peixoto, M Relvas-Santos, R Azevedo… - Frontiers in …, 2019 - frontiersin.org
Decades of research have disclosed a plethora of alterations in protein glycosylation that
decisively impact in all stages of disease and ultimately contribute to more aggressive cell …

[HTML][HTML] Targeting cancer hallmarks with epigallocatechin gallate (EGCG): mechanistic basis and therapeutic targets

WH Talib, D Awajan, A Alqudah, R Alsawwaf… - Molecules, 2024 - mdpi.com
Epigallocatechin gallate (EGCG) is a catechin, which is a type of flavonoid found in high
concentrations in green tea. EGCG has been studied extensively for its potential health …

NF-κB pathways in the development and progression of colorectal cancer

M Patel, PG Horgan, DC McMillan, J Edwards - Translational Research, 2018 - Elsevier
Nuclear factor-κB (NF-κB) has been widely implicated in the development and progression
of cancer. In colorectal cancer (CRC), NF-κB has a key role in cancer-related processes …

[HTML][HTML] Natural products for treating colorectal cancer: A mechanistic review

X Huang, Z Yang, Q **e, Z Zhang, H Zhang… - Biomedicine & …, 2019 - Elsevier
Colorectal cancer (CRC) is one of the most common types of cancers in humans and is
closely linked to the global cancer-related mortalities worldwide. Molecular pathological …

Interactome battling of lncRNA CCDC144NL-AS1: Its role in the emergence and ferocity of cancer and beyond

YK Abd El Fattah, AI Abulsoud, SG AbdelHamid… - International Journal of …, 2022 - Elsevier
Long non-coding RNAs (lncRNAs) were, once, viewed as “noise” for transcription. Recently,
many lncRNAs are functionally linked to several human disorders, including cancer. Coiled …

Allicin and cancer hallmarks

WH Talib, MM Baban, AO Azzam, JJ Issa, AY Ali… - Molecules, 2024 - mdpi.com
Natural products, particularly medicinal plants, are crucial in combating cancer and aiding in
the discovery and development of new therapeutic agents owing to their biologically active …

[HTML][HTML] Therapeutic targeting of the IGF axis

E Osher, VM Macaulay - Cells, 2019 - mdpi.com
The insulin like growth factor (IGF) axis plays a fundamental role in normal growth and
development, and when deregulated makes an important contribution to disease. Here, we …