Adaptive responses to hypoxia and/or hyperoxia in humans
Significance: Oxygen is indispensable for aerobic life, but its utilization exposes cells and
tissues to oxidative stress; thus, tight regulation of cellular, tissue, and systemic oxygen …
tissues to oxidative stress; thus, tight regulation of cellular, tissue, and systemic oxygen …
Manipulating mitochondrial electron flow enhances tumor immunogenicity
Although tumor growth requires the mitochondrial electron transport chain (ETC), the relative
contribution of complex I (CI) and complex II (CII), the gatekeepers for initiating electron flow …
contribution of complex I (CI) and complex II (CII), the gatekeepers for initiating electron flow …
The multifaceted ATPase inhibitory factor 1 (IF1) in energy metabolism reprogramming and mitochondrial dysfunction: a new player in age-associated disorders?
E Gore, T Duparc, A Genoux, B Perret… - Antioxidants & Redox …, 2022 - liebertpub.com
Significance: The mitochondrial oxidative phosphorylation (OXPHOS) system, comprising
the electron transport chain and ATP synthase, generates membrane potential, drives ATP …
the electron transport chain and ATP synthase, generates membrane potential, drives ATP …
IF1 ablation prevents ATP synthase oligomerization, enhances mitochondrial ATP turnover and promotes an adenosine-mediated pro-inflammatory phenotype
S Domínguez-Zorita, I Romero-Carramiñana… - Cell Death & …, 2023 - nature.com
Abstract ATPase Inhibitory Factor 1 (IF1) regulates the activity of mitochondrial ATP
synthase. The expression of IF1 in differentiated human and mouse cells is highly variable …
synthase. The expression of IF1 in differentiated human and mouse cells is highly variable …
Molecular mechanism on forcible ejection of ATPase inhibitory factor 1 from mitochondrial ATP synthase
IF1 is a natural inhibitor protein for mitochondrial FoF1 ATP synthase that blocks catalysis
and rotation of the F1 by deeply inserting its N-terminal helices into F1. A unique feature of …
and rotation of the F1 by deeply inserting its N-terminal helices into F1. A unique feature of …
IF1 promotes oligomeric assemblies of sluggish ATP synthase and outlines the heterogeneity of the mitochondrial membrane potential
I Romero-Carramiñana, PB Esparza-Moltó… - Communications …, 2023 - nature.com
The coexistence of two pools of ATP synthase in mitochondria has been largely neglected
despite in vitro indications for the existence of reversible active/inactive state transitions in …
despite in vitro indications for the existence of reversible active/inactive state transitions in …
[HTML][HTML] Boosting mitochondrial health to counteract neurodegeneration
Mitochondrial health is based on a delicate balance of specific mitochondrial functions (eg
metabolism, signaling, dynamics) that are impaired in neurodegenerative diseases …
metabolism, signaling, dynamics) that are impaired in neurodegenerative diseases …
[HTML][HTML] Human IPSC 3D brain model as a tool to study chemical-induced dopaminergic neuronal toxicity
Oxidative stress is caused by an imbalance between the generation and detoxification of
reactive oxygen and nitrogen species (ROS/RNS). This imbalance plays an important role in …
reactive oxygen and nitrogen species (ROS/RNS). This imbalance plays an important role in …
Multifaceted roles of mitochondrial stress responses under ETC dysfunction–repair, destruction and pathogenesis
Electron transport chain (ETC) dysfunction is a common feature of mitochondrial diseases
and induces severe cellular stresses, including mitochondrial membrane potential (Δψm) …
and induces severe cellular stresses, including mitochondrial membrane potential (Δψm) …
How the disruption of mitochondrial redox signalling contributes to ageing
In the past, mitochondrial reactive oxygen species (mtROS) were considered a byproduct of
cellular metabolism. Due to the capacity of mtROS to cause oxidative damage, they were …
cellular metabolism. Due to the capacity of mtROS to cause oxidative damage, they were …