With increasing evidence that microbes colonize tumors, synthetic biology tools are being
leveraged to repurpose bacteria as tumor-specific delivery systems. These engineered …

Directed evolution aims to expedite the natural evolution process of biological molecules
and systems in a test tube through iterative rounds of gene diversifications and library …

The steadfast advance of the synthetic biology field has enabled scientists to use genetically
engineered cells, instead of small molecules or biologics, as the basis for the development …

Recent advances in cancer therapeutics, such as targeted therapy and immunotherapy,
have raised the hope for cures for many cancer types. However, there are still ongoing …

Checkpoint inhibitors have revolutionized cancer therapy but only work in a subset of
patients and can lead to a multitude of toxicities, suggesting the need for more targeted …

A host's microbiota may increase, diminish, or have no effect at all on cancer susceptibility.
Assigning causal roles in cancer to specific microbes and microbiotas, unraveling host …

Microbial biodiversity includes biotic and abiotic components that support all life forms by
adapting to environmental conditions. Climate change, pollution, human activity, and natural …

We consider detection based on deep learning, and show it is possible to train detectors that
perform well without any knowledge of the underlying channel models. Moreover, when the …

The ability to rationally engineer microorganisms has been a long-envisioned goal dating
back more than a half-century. With the genomics revolution and rise of systems biology in …

Cells navigate environments, communicate and build complex patterns by initiating gene
expression in response to specific signals. Engineers seek to harness this capability to …