Molecular pathology of neurodegenerative diseases by cryo-EM of amyloids
Abnormal assembly of tau, α-synuclein, TDP-43 and amyloid-β proteins into amyloid
filaments defines most human neurodegenerative diseases. Genetics provides a direct link …
filaments defines most human neurodegenerative diseases. Genetics provides a direct link …
Amyloid oligomers: A joint experimental/computational perspective on Alzheimer's disease, Parkinson's disease, type II diabetes, and amyotrophic lateral sclerosis
Protein misfolding and aggregation is observed in many amyloidogenic diseases affecting
either the central nervous system or a variety of peripheral tissues. Structural and dynamic …
either the central nervous system or a variety of peripheral tissues. Structural and dynamic …
Structure-based classification of tauopathies
The ordered assembly of tau protein into filaments characterizes several neurodegenerative
diseases, which are called tauopathies. It was previously reported that, by cryo-electron …
diseases, which are called tauopathies. It was previously reported that, by cryo-electron …
Tauopathies: new perspectives and challenges
Y Zhang, KM Wu, L Yang, Q Dong, JT Yu - Molecular neurodegeneration, 2022 - Springer
Background Tauopathies are a class of neurodegenerative disorders characterized by
neuronal and/or glial tau-positive inclusions. Main body Clinically, tauopathies can present …
neuronal and/or glial tau-positive inclusions. Main body Clinically, tauopathies can present …
Mechanisms and pathology of protein misfolding and aggregation
Despite advances in machine learning-based protein structure prediction, we are still far
from fully understanding how proteins fold into their native conformation. The conventional …
from fully understanding how proteins fold into their native conformation. The conventional …
The expanding amyloid family: Structure, stability, function, and pathogenesis
The hidden world of amyloid biology has suddenly snapped into atomic-level focus,
revealing over 80 amyloid protein fibrils, both pathogenic and functional. Unlike globular …
revealing over 80 amyloid protein fibrils, both pathogenic and functional. Unlike globular …
Assembly of recombinant tau into filaments identical to those of Alzheimer's disease and chronic traumatic encephalopathy
Abundant filamentous inclusions of tau are characteristic of more than 20
neurodegenerative diseases that are collectively termed tauopathies. Electron cryo …
neurodegenerative diseases that are collectively termed tauopathies. Electron cryo …
Disease-specific tau filaments assemble via polymorphic intermediates
Intermediate species in the assembly of amyloid filaments are believed to play a central role
in neurodegenerative diseases and may constitute important targets for therapeutic …
in neurodegenerative diseases and may constitute important targets for therapeutic …
Amyloid fibrils in FTLD-TDP are composed of TMEM106B and not TDP-43
Frontotemporal lobar degeneration (FTLD) is the third most common neurodegenerative
condition after Alzheimer's and Parkinson's diseases. FTLD typically presents in 45 to 64 …
condition after Alzheimer's and Parkinson's diseases. FTLD typically presents in 45 to 64 …
Structures of α-synuclein filaments from multiple system atrophy
Synucleinopathies, which include multiple system atrophy (MSA), Parkinson's disease,
Parkinson's disease with dementia and dementia with Lewy bodies (DLB), are human …
Parkinson's disease with dementia and dementia with Lewy bodies (DLB), are human …