Structure− brain exposure relationships

SA Hitchcock, LD Pennington - Journal of medicinal chemistry, 2006 - ACS Publications
Healthy functioning of the human brain relies on effective shielding of the sensitive neural
microenvironment from potentially disruptive xenobiotic agents circulating in the periphery …

[HTML][HTML] Quinoxaline: A comprehension of current pharmacological advancement in medicinal chemistry

SK Suthar, NS Chundawat, GP Singh… - European Journal of …, 2022 - Elsevier
Quinoxaline is a fused heterocycle ring template present in diverse pharmacophore and
widely used in medicinal chemistry. Owing to its vast pharmaceutical profile, several …

A perspective review on fatty acid amide hydrolase (FAAH) inhibitors as potential therapeutic agents

RKP Tripathi - European Journal of Medicinal Chemistry, 2020 - Elsevier
Fatty acid amide hydrolase (FAAH) is an important enzyme creditworthy of hydrolyzing
endocannabinoids and related-amidated signalling lipids, discovery of which has pioneered …

Functions of 5-HT2A receptor and its antagonists in the cardiovascular system

T Nagatomo, M Rashid, HA Muntasir… - Pharmacology & …, 2004 - Elsevier
The serotonin (5-hydroxytryptamine, 5-HT) receptors have conventionally been divided into
seven subfamilies, most of which have several subtypes. Among them, 5-HT2A receptor is …

Dimethyl sulfoxide involved one-pot synthesis of quinoxaline derivatives

C **e, Z Zhang, D Li, J Gong, X Han… - The Journal of organic …, 2017 - ACS Publications
An efficient, green, and novel method for the synthesis of N-heterocycle-fused quinoxalines
is reported herein. Dimethyl sulfoxide was used as both a reactant and a solvent in this …

Present status of quinoxaline motifs: Excellent pathfinders in therapeutic medicine

OO Ajani - European journal of medicinal chemistry, 2014 - Elsevier
Quinoxalines belong to a class of excellent heterocyclic scaffolds owing to their wide
biological properties and diverse therapeutic applications in medicinal research. They are …

Current methods for the synthesis of 2-substituted azoles

CA Zificsak, DJ Hlasta - Tetrahedron, 2004 - Elsevier
1, 3 Azoles are important as heterocyclic components of many natural products, drugs, and
biologically active molecules. 1, 2 Consequently, new, efficient methodologies for the …

Recent advances with 5‐HT3 modulators for neuropsychiatric and gastrointestinal disorders

R Juza, P Vlcek, E Mezeiova, K Musilek… - Medicinal research …, 2020 - Wiley Online Library
Abstract Serotonin (5‐hydroxytryptophan [5‐HT]) is a biologically active amine expressed in
platelets, in gastrointestinal (GI) cells and, to a lesser extent, in the central nervous system …

New ferrocenic pyrrolo [1, 2-a] quinoxaline derivatives: Synthesis, and in vitro antimalarial activity–Part II

J Guillon, E Mouray, S Moreau, C Mullié, I Forfar… - European journal of …, 2011 - Elsevier
Following our search for antimalarial compounds, novel series of ferrocenyl-substituted
pyrrolo [1, 2-a] quinoxalines 1-2 were synthesized from ferrocene-carboxaldehyde and …

Quinoxalinylethylpyridylthioureas (QXPTs) as potent non-nucleoside HIV-1 reverse transcriptase (RT) inhibitors. Further SAR studies and identification of a novel …

G Campiani, F Aiello, M Fabbrini, E Morelli… - Journal of medicinal …, 2001 - ACS Publications
Quinoxalinylethylpyridylthioureas (QXPTs) represent a new class of human
immunodeficiency virus type 1 (HIV-1) non-nucleoside reverse transcriptase (RT) inhibitors …