Structure− brain exposure relationships
SA Hitchcock, LD Pennington - Journal of medicinal chemistry, 2006 - ACS Publications
Healthy functioning of the human brain relies on effective shielding of the sensitive neural
microenvironment from potentially disruptive xenobiotic agents circulating in the periphery …
microenvironment from potentially disruptive xenobiotic agents circulating in the periphery …
[HTML][HTML] Quinoxaline: A comprehension of current pharmacological advancement in medicinal chemistry
SK Suthar, NS Chundawat, GP Singh… - European Journal of …, 2022 - Elsevier
Quinoxaline is a fused heterocycle ring template present in diverse pharmacophore and
widely used in medicinal chemistry. Owing to its vast pharmaceutical profile, several …
widely used in medicinal chemistry. Owing to its vast pharmaceutical profile, several …
A perspective review on fatty acid amide hydrolase (FAAH) inhibitors as potential therapeutic agents
RKP Tripathi - European Journal of Medicinal Chemistry, 2020 - Elsevier
Fatty acid amide hydrolase (FAAH) is an important enzyme creditworthy of hydrolyzing
endocannabinoids and related-amidated signalling lipids, discovery of which has pioneered …
endocannabinoids and related-amidated signalling lipids, discovery of which has pioneered …
Functions of 5-HT2A receptor and its antagonists in the cardiovascular system
T Nagatomo, M Rashid, HA Muntasir… - Pharmacology & …, 2004 - Elsevier
The serotonin (5-hydroxytryptamine, 5-HT) receptors have conventionally been divided into
seven subfamilies, most of which have several subtypes. Among them, 5-HT2A receptor is …
seven subfamilies, most of which have several subtypes. Among them, 5-HT2A receptor is …
Dimethyl sulfoxide involved one-pot synthesis of quinoxaline derivatives
C **e, Z Zhang, D Li, J Gong, X Han… - The Journal of organic …, 2017 - ACS Publications
An efficient, green, and novel method for the synthesis of N-heterocycle-fused quinoxalines
is reported herein. Dimethyl sulfoxide was used as both a reactant and a solvent in this …
is reported herein. Dimethyl sulfoxide was used as both a reactant and a solvent in this …
Present status of quinoxaline motifs: Excellent pathfinders in therapeutic medicine
OO Ajani - European journal of medicinal chemistry, 2014 - Elsevier
Quinoxalines belong to a class of excellent heterocyclic scaffolds owing to their wide
biological properties and diverse therapeutic applications in medicinal research. They are …
biological properties and diverse therapeutic applications in medicinal research. They are …
Current methods for the synthesis of 2-substituted azoles
CA Zificsak, DJ Hlasta - Tetrahedron, 2004 - Elsevier
1, 3 Azoles are important as heterocyclic components of many natural products, drugs, and
biologically active molecules. 1, 2 Consequently, new, efficient methodologies for the …
biologically active molecules. 1, 2 Consequently, new, efficient methodologies for the …
Recent advances with 5‐HT3 modulators for neuropsychiatric and gastrointestinal disorders
Abstract Serotonin (5‐hydroxytryptophan [5‐HT]) is a biologically active amine expressed in
platelets, in gastrointestinal (GI) cells and, to a lesser extent, in the central nervous system …
platelets, in gastrointestinal (GI) cells and, to a lesser extent, in the central nervous system …
New ferrocenic pyrrolo [1, 2-a] quinoxaline derivatives: Synthesis, and in vitro antimalarial activity–Part II
Following our search for antimalarial compounds, novel series of ferrocenyl-substituted
pyrrolo [1, 2-a] quinoxalines 1-2 were synthesized from ferrocene-carboxaldehyde and …
pyrrolo [1, 2-a] quinoxalines 1-2 were synthesized from ferrocene-carboxaldehyde and …
Quinoxalinylethylpyridylthioureas (QXPTs) as potent non-nucleoside HIV-1 reverse transcriptase (RT) inhibitors. Further SAR studies and identification of a novel …
Quinoxalinylethylpyridylthioureas (QXPTs) represent a new class of human
immunodeficiency virus type 1 (HIV-1) non-nucleoside reverse transcriptase (RT) inhibitors …
immunodeficiency virus type 1 (HIV-1) non-nucleoside reverse transcriptase (RT) inhibitors …