The epithelial–mesenchymal plasticity landscape: principles of design and mechanisms of regulation
Epithelial–mesenchymal plasticity (EMP) enables cells to interconvert between several
states across the epithelial–mesenchymal landscape, thereby acquiring hybrid epithelial …
states across the epithelial–mesenchymal landscape, thereby acquiring hybrid epithelial …
Targeting signaling pathways in prostate cancer: mechanisms and clinical trials
Developmental cell programs are co-opted in inflammatory skin disease
INTRODUCTION Human skin provides vital protection from water loss and from external
insult through structural adaptations and interplay with the innate and adaptive immune …
insult through structural adaptations and interplay with the innate and adaptive immune …
Landscape of prostate-specific membrane antigen heterogeneity and regulation in AR-positive and AR-negative metastatic prostate cancer
Tumor expression of prostate-specific membrane antigen (PSMA) is lost in 15–20% of men
with castration-resistant prostate cancer (CRPC), yet the underlying mechanisms remain …
with castration-resistant prostate cancer (CRPC), yet the underlying mechanisms remain …
EZH2 inhibition activates a dsRNA–STING–interferon stress axis that potentiates response to PD-1 checkpoint blockade in prostate cancer
Prostate cancers are considered to be immunologically 'cold'tumors given the very few
patients who respond to checkpoint inhibitor (CPI) therapy. Recently, enrichment of …
patients who respond to checkpoint inhibitor (CPI) therapy. Recently, enrichment of …
The efficacy of PD-1/PD-L1 blockade in cold cancers and future perspectives
J Majidpoor, K Mortezaee - Clinical Immunology, 2021 - Elsevier
Colorectal cancer (CRC), and breast, ovarian, pancreatic and prostate cancers are generally
considered as low immune-reactive cancers that represent either limited infiltration of …
considered as low immune-reactive cancers that represent either limited infiltration of …
Integrated analyses highlight interactions between the three-dimensional genome and DNA, RNA and epigenomic alterations in metastatic prostate cancer
The impact of variations in the three-dimensional structure of the genome has been
recognized, but solid cancer tissue studies are limited. Here, we performed integrated deep …
recognized, but solid cancer tissue studies are limited. Here, we performed integrated deep …
An androgen receptor switch underlies lineage infidelity in treatment-resistant prostate cancer
Cancers adapt to increasingly potent targeted therapies by reprogramming their phenotype.
Here we investigated such a phenomenon in prostate cancer, in which tumours can escape …
Here we investigated such a phenomenon in prostate cancer, in which tumours can escape …
MYC drives aggressive prostate cancer by disrupting transcriptional pause release at androgen receptor targets
Abstract c-MYC (MYC) is a major driver of prostate cancer tumorigenesis and progression.
Although MYC is overexpressed in both early and metastatic disease and associated with …
Although MYC is overexpressed in both early and metastatic disease and associated with …