Since the 1960s, methicillin-resistant Staphylococcus aureus (MRSA) has emerged,
disseminated globally and become a leading cause of bacterial infections in both health …

In order to retard the rate of development of antibacterial resistance, the causative agent
must be identified as rapidly as possible, so that directed patient treatment and/or contact …

Background Community-acquired pneumonia is a leading infectious cause of hospitalization
and death among US adults. Incidence estimates of pneumonia confirmed radiographically …

Background Efforts to develop an evidence-based approach to the evaluation and
management of young febrile infants have spanned more than 4 decades. 1 In the 1970s …

Background Incidence estimates of hospitalizations for community-acquired pneumonia
among children in the United States that are based on prospective data collection are …

Background. The value of rapid, panel-based molecular diagnostics for positive blood
culture bottles (BCBs) has not been rigorously assessed. We performed a prospective …

Blood culture remains the best approach to identify the incriminating microorganisms when
a bloodstream infection is suspected, and to guarantee that the antimicrobial treatment is …

Timely and accurate identification and determination of the antimicrobial susceptibility of
uropathogens is central to the management of UTIs. Urine dipsticks are fast and amenable …

Nearly 40 years have elapsed since the invention of the PCR, with its extremely sensitive
and specific ability to detect nucleic acids via in vitro enzyme-mediated amplification. In turn …

New rapid molecular diagnostic technologies for infectious diseases enable expedited
accurate microbiological diagnoses. However, diagnostic stewardship and antimicrobial …