The intrinsic cardiac nervous system and its role in cardiac pacemaking and conduction

L Fedele, T Brand - Journal of cardiovascular development and disease, 2020 - mdpi.com
The cardiac autonomic nervous system (CANS) plays a key role for the regulation of cardiac
activity with its dysregulation being involved in various heart diseases, such as cardiac …

Heart function and hemodynamic analysis for zebrafish embryos

HC Yalcin, A Amindari, JT Butcher… - Developmental …, 2017 - Wiley Online Library
The Zebrafish has emerged to become a powerful vertebrate animal model for
cardiovascular research in recent years. Its advantages include easy genetic manipulation …

Mechanisms of heart valve development and disease

A O'Donnell, KE Yutzey - Development, 2020 - journals.biologists.com
The valves of the heart are crucial for ensuring that blood flows in one direction from the
heart, through the lungs and back to the rest of the body. Heart valve development is …

Using zebrafish for investigating the molecular mechanisms of drug‐induced cardiotoxicity

ZZ Zakaria, FM Benslimane… - BioMed research …, 2018 - Wiley Online Library
Over the last decade, the zebrafish (Danio rerio) has emerged as a model organism for
cardiovascular research. Zebrafish have several advantages over mammalian models. For …

[HTML][HTML] The posterity of Zebrafish in paradigm of in vivo molecular toxicological profiling

SK Verma, A Nandi, A Sinha, P Patel, S Mohanty… - Biomedicine & …, 2024 - Elsevier
The aggrandised advancement in utility of advanced day-to-day materials and
nanomaterials has raised serious concern on their biocompatibility with human and other …

[HTML][HTML] A beginner's guide to understanding and implementing the genetic modification of zebrafish

SA Rafferty, TA Quinn - Progress in biophysics and molecular biology, 2018 - Elsevier
Zebrafish are a relevant and useful vertebrate model species to study normal-and patho-
physiology, including that of the heart, due to conservation of protein-coding genes, organ …

[HTML][HTML] Pharmacological assessment of zebrafish-based cardiotoxicity models

M Maciag, A Wnorowski, M Mierzejewska… - Biomedicine & …, 2022 - Elsevier
Cardiotoxicity remains the most common reason for failure during drug development.
Recently, the zebrafish (Danio rerio) model has emerged for the evaluation of drug …

Exposure to acrylamide induces cardiac developmental toxicity in zebrafish during cardiogenesis

M Huang, J Jiao, J Wang, Z **a, Y Zhang - Environmental Pollution, 2018 - Elsevier
Acrylamide (AA), an environmental pollutant, has been linked to neurotoxicity, genotoxicity
and carcinogenicity. AA is widely used to synthesize polymers for industrial applications, is …

[HTML][HTML] Zebrafish as a model to study vascular elastic fibers and associated pathologies

M Hoareau, N El Kholti, R Debret… - International Journal of …, 2022 - mdpi.com
Many extensible tissues such as skin, lungs, and blood vessels require elasticity to function
properly. The recoil of elastic energy stored during a stretching phase is provided by elastic …

Small fish, big discoveries: zebrafish shed light on microbial biomarkers for neuro-immune-cardiovascular health

H Sree Kumar, AS Wisner, JM Refsnider… - Frontiers in …, 2023 - frontiersin.org
Zebrafish (Danio rerio) have emerged as a powerful model to study the gut microbiome in
the context of human conditions, including hypertension, cardiovascular disease …