The AMPK (AMP-activated protein kinase) and TOR (target-of-rapamycin) pathways are
interlinked, opposing signaling pathways involved in sensing availability of nutrients and …

Cells and organisms must coordinate their metabolic activity with changes in their
environment to ensure their growth only when conditions are favourable. In order to maintain …

The mechanistic target of rapamycin complex 1 (mTORC1) is a master regulator of cell
growth that responds to a diverse set of environmental inputs, including amino acids. Over …

The protein kinase mechanistic target of rapamycin (mTOR) functions as a central regulator
of metabolism, integrating diverse nutritional and hormonal cues to control anabolic …

Coordinating cell growth with nutrient availability is critical for cell survival. The evolutionarily
conserved TOR (target of rapamycin) controls cell growth in response to nutrients, in …

The mechanistic target of rapamycin complex 1 (mTORC1) coordinates cellular growth and
metabolism with environmental inputs to ensure that cells grow only under favourable …

For the past five decades, the lysosome has been characterized as an unglamorous cellular
recycling center. This notion has undergone a radical shift in the last 10 years, with new …

The macronutrients glucose, lipids, and amino acids are the major components that maintain
life. The ability of cells to sense and respond to fluctuations in these nutrients is a crucial …

The evolutionarily conserved target of rapamycin complex 1 (TORC1) couples an array of
intra-and extracellular stimuli to cell growth, proliferation and metabolism, and its …

The Target of Rapamycin (TOR) is a highly conserved serine/threonine protein kinase that
performs essential roles in the control of cellular growth and metabolism. TOR acts in two …