Housekee** genes are involved in basic cell maintenance and, therefore, are expected to
maintain constant expression levels in all cells and conditions. Identification of these genes …

There is now compelling evidence that the complexity of higher organisms correlates with
the relative amount of non-coding RNA rather than the number of protein-coding genes …

Over one million candidate regulatory elements have been identified across the human
genome, but nearly all are unvalidated and their target genes uncertain. Approaches based …

Ceramide is an important lipid signaling molecule and a key intermediate in sphingolipid
biosynthesis. Recent studies have implied a previously unappreciated role for the ceramide …

Background The human genome contains over one million Alu repeat elements whose
distribution is not uniform. While metabolism-related genes were shown to be enriched with …

While less than 1.5% of the mammalian genome encodes proteins, it is now evident that the
vast majority is transcribed, mainly into non-protein-coding RNAs. This raises the question of …

Background This study aims to characterize the housekee** and tissue-specific genes in
15 mouse tissues by using the serial analysis of gene expression (SAGE) strategy which …

Background The assay for transposase-accessible chromatin (ATAC-seq) is a powerful
method to examine chromatin accessibility. While many studies have reported a positive …

The application of deep sequencing to map 5′ capped transcripts has confirmed the
existence of at least two distinct promoter classes in metazoans:“focused” promoters with …

Background Housekee** (HK) genes are ubiquitously expressed in all tissue/cell types
and constitute a basal transcriptome for the maintenance of basic cellular functions …