Insulin-like growth factor 2 mRNA-binding proteins (IGF2BPs): post-transcriptional drivers of cancer progression?

JL Bell, K Wächter, B Mühleck, N Pazaitis… - Cellular and molecular …, 2013 - Springer
The insulin-like growth factor-2 mRNA-binding proteins 1, 2, and 3 (IGF2BP1, IGF2BP2,
IGF2BP3) belong to a conserved family of RNA-binding, oncofetal proteins. Several studies …

[HTML][HTML] The role of the oncofetal IGF2 mRNA-binding protein 3 (IGF2BP3) in cancer

M Lederer, N Bley, C Schleifer, S Hüttelmaier - Seminars in cancer biology, 2014 - Elsevier
The post-transcriptional control of gene expression mediated by RNA-binding proteins
(RBPs), long non-coding RNAs (lncRNAs) as well as miRNAs is essential to determine …

EWSR1-induced circNEIL3 promotes glioma progression and exosome-mediated macrophage immunosuppressive polarization via stabilizing IGF2BP3

Z Pan, R Zhao, B Li, Y Qi, W Qiu, Q Guo, S Zhang… - Molecular cancer, 2022 - Springer
Background Gliomas are the most common malignant primary brain tumours with a highly
immunosuppressive tumour microenvironment (TME) and poor prognosis. Circular RNAs …

DMDRMR-Mediated Regulation of m6A-Modified CDK4 by m6A Reader IGF2BP3 Drives ccRCC Progression

Y Gu, S Niu, Y Wang, L Duan, Y Pan, Z Tong, X Zhang… - Cancer research, 2021 - AACR
Abstract Aberrant N 6-methyladenosine (m6A) modification has emerged as a driver of
tumor initiation and progression, yet how long noncoding RNAs (lncRNA) are involved in the …

A circular RNA activated by TGFβ promotes tumor metastasis through enhancing IGF2BP3-mediated PDPN mRNA stability

K Li, J Guo, Y Ming, S Chen, T Zhang, H Ma… - Nature …, 2023 - nature.com
Metastasis is the leading cause of cancer-related death, where TGFβ-induced epithelial-
mesenchymal transition (EMT) process confers on cancer cells increased metastatic …

IGF2BP3 facilitates cell proliferation and tumorigenesis via modulation of JAK/STAT signalling pathway in human bladder cancer

W Huang, Y Li, C Zhang, H Zha, X Zhou… - Journal of cellular …, 2020 - Wiley Online Library
Insulin‐like growth factor‐2 messenger RNA‐binding protein 3 (IGF2BP3) has been
reported to contribute to tumorigenesis in several human cancers. However, the biological …

Oncofetal protein IGF2BPs in human cancer: functions, mechanisms and therapeutic potential

TY Zhu, LL Hong, ZQ Ling - Biomarker research, 2023 - Springer
Abstract N6-methyladenosine (m6A) is the most prevalent and well-characterized internal
chemical modification in eukaryotic RNA, influencing gene expression and phenotypic …

Prognostic factors and predictive models in renal cell carcinoma: a contemporary review

M Sun, SF Shariat, C Cheng, V Ficarra, M Murai… - European urology, 2011 - Elsevier
CONTEXT: The natural history of renal cell carcinoma (RCC) is highly unpredictable. Small
renal masses may be accompanied by metastatic disease. Conversely, patients with locally …

Personalized immunotherapy against several neuronal and brain tumors

S Kuttruff-coqui, T Weinschenk, J Fritsche… - US Patent …, 2021 - Google Patents
2014-11-12 Assigned to IMMATICS BIOTECHNOLOGIES GMBH reassignment IMMATICS
BIOTECHNOLOGIES GMBH ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT …

Clear cell carcinoma of the ovary: a report from the first Ovarian Clear Cell Symposium, June 24th, 2010

MS Anglesio, MS Carey, M Köbel, H MacKay… - Gynecologic …, 2011 - Elsevier
OBJECTIVES: Recent literature has highlighted histological types of ovarian carcinoma as
distinct diseases, each with unique clinical and molecular features. Historically, the …