Inflammation and the two-hit hypothesis of schizophrenia

KA Feigenson, AW Kusnecov, SM Silverstein - … & Biobehavioral Reviews, 2014 - Elsevier
The high societal and individual cost of schizophrenia necessitates finding better, more
effective treatment, diagnosis, and prevention strategies. One of the obstacles in this …

Chemokines and chemokine receptors in mood disorders, schizophrenia, and cognitive impairment: a systematic review of biomarker studies

MJ Stuart, BT Baune - Neuroscience & Biobehavioral Reviews, 2014 - Elsevier
The search for immune biomarkers in psychiatric disorders has primarily focused on pro-
inflammatory cytokines. Other immune proteins including chemokines have been relatively …

Increased prevalence of diverse N-methyl-D-aspartate glutamate receptor antibodies in patients with an initial diagnosis of schizophrenia: specific relevance of IgG …

J Steiner, M Walter, W Glanz, Z Sarnyai… - JAMA …, 2013 - jamanetwork.com
Context Evidence for symptomatic convergence of schizophrenia and N-methyl-D-aspartate
glutamate receptor (NMDA-R) encephalitis highlights the need for an assessment of …

Convergent functional genomics of schizophrenia: from comprehensive understanding to genetic risk prediction

M Ayalew, H Le-Niculescu, DF Levey, N Jain… - Molecular …, 2012 - nature.com
We have used a translational convergent functional genomics (CFG) approach to identify
and prioritize genes involved in schizophrenia, by gene-level integration of genome-wide …

A systematic review of metabolite biomarkers of schizophrenia

J Davison, A O'Gorman, L Brennan, DR Cotter - Schizophrenia research, 2018 - Elsevier
Current diagnosis of schizophrenia relies exclusively on the potentially subjective
interpretation of clinical symptoms and social functioning as more objective biological …

Towards a psychosis risk blood diagnostic for persons experiencing high-risk symptoms: preliminary results from the NAPLS project

DO Perkins, CD Jeffries, J Addington… - Schizophrenia …, 2015 - academic.oup.com
Introduction: A barrier to preventative treatments for psychosis is the absence of accurate
identification of persons at highest risk. A blood test that could substantially increase …

Role of inflammation in the pathogenesis of schizophrenia: A review of the evidence, proposed mechanisms and implications for treatment

D Mongan, M Ramesar, M Föcking… - Early intervention in …, 2020 - Wiley Online Library
Aim Over the past several decades, there has been a growing research interest in the role of
inflammation in the pathogenesis of schizophrenia. This review aims to summarize evidence …

Markers of inflammation and stress distinguish subsets of individuals with schizophrenia and bipolar disorder

SG Fillman, D Sinclair, SJ Fung, MJ Webster… - Translational …, 2014 - nature.com
Schizophrenia and bipolar disorder share a number of common features, both
symptomatically and biologically. Abnormalities in the neuroimmune and the stress …

Innate immune cells and C-reactive protein in acute first-episode psychosis and schizophrenia: relationship to psychopathology and treatment

J Steiner, T Frodl, K Schiltz, H Dobrowolny… - Schizophrenia …, 2020 - academic.oup.com
Innate immunity has been linked to initiation of Alzheimer's disease and multiple sclerosis.
Moreover, risk of first-episode psychosis (FEP) and schizophrenia (Sz) is increased after …

Biomarkers in schizophrenia: A focus on blood based diagnostics and theranostics

CY Lai, E Scarr, M Udawela, I Everall… - World journal of …, 2016 - pmc.ncbi.nlm.nih.gov
Identifying biomarkers that can be used as diagnostics or predictors of treatment response
(theranostics) in people with schizophrenia (Sz) will be an important step towards being able …