Histone lysine methylation is a key epigenetic modification that regulates eukaryotic
transcription. Here, we comprehensively review the function and regulation of the histone …

H3K36 methylation is a critical histone modification involved in transcription regulation. It
involves the mono (H3K36me1), di (H3K36me2), and/or tri-methylation (H3K36me3) of …

The chromatin-modifying histone deacetylases (HDACs) remove acetyl groups from acetyl-
lysine residues in histone amino-terminal tails, thereby mediating transcriptional repression …

Prolonged exposure to manganese (Mn) contributes to hippocampal Mn accumulation,
which leads to neurodegenerative diseases called manganese poisoning. However, the …

Background Cellular senescence is a critical factor contributing to osteoarthritis (OA).
Overexpression of chromobox homolog 4 (CBX4) in a mouse system was demonstrated to …

H3K4 methylation by Set1-COMPASS (complex of proteins associated with Set1) is a
conserved histone modification. Although it is critical for gene regulation, the …

Transcriptional regulation mediated by the balance of histone acetylation and deacetylation
is fundamental in responding to environmental cues by impacting chromatin remodeling …

TFE3-rearranged renal cell cancer (tRCC) is a rare form of RCC that involves chromosomal
translocation of the Xp11. 2 TFE3 gene. Despite its early onset and poor prognosis, the …

Nucleosome‐depleted regions (NDRs) at gene promoters support initiation of RNA
polymerase II transcription. Interestingly, transcription often initiates in both directions …

SET domain-containing 2 (SETD2) is a lysine methyltransferase that catalyzes histone H3
lysine36 trimethylation (H3K36me3) and has been revealed to play important roles in the …